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INNATE IMMUNE REGULATION OF METABOLIC SYNDROME

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Title INNATE IMMUNE REGULATION OF METABOLIC SYNDROME
 
Creator Ghosh, Amrit Raj
 
Subject Cancer Biology and Inflammatory Disorder Division
 
Description Evolution of multicellular organisms from unicellular ones was focussed mainly around the availability of nutrients. Ability of mammals to cope with this nutrient limitation through control of its usage and storage internally gives us survival advantage over other organisms (1). But during this evolution the focus was put mainly on conserving nutrients within the body when there was scarcity in the surroundings, but now our metabolic system is challenged with a unique and unprecedented problem which is nutrient excess. Its seems our evolution was so focussed on the conservation of the nutrients; the present situation of the nutrient excess has become a baffling problem for our system. This scenario is especially evident in developing and developed world, where obesity and associated metabolic disorders have become an epidemic. Normally metabolism and immune system were thought to be different entities, but now their role in shaping up each other is being well appreciated (2). It has been proposed that the immune system can sense and if required can impact the metabolic state of the body and depending on which it can either assume inflammatory or regulatory role in the metabolically active tissues (3)
With ever increasing burden of metabolic syndrome on medical expenses around the world reaching astronomic levels and concomitant rise in the incidence of obesity, the aforementioned association of immune system and obesity associated metabolic syndrome is under spotlight with a hope to manage this epidemic through tweaking their interplay. The role of immune system in our body extends beyond protection from invading pathogens as it plays a major role in shaping out systemic metabolism.
Apart from its role in autoimmune disease like type 1 diabetes where immune cells destroy pancreatic beta cells and disrupt glucose homeostasis, obesity associated inflammation also plays a significant role in the development of insulin resistance, which is inability to respond to circulating insulin that in turn disrupts glucose homeostasis and is central to the etiology of type 2 diabetes (1,2).
 
Date 2018
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/2767/1/Amrit_Raj_Ghosh_Thesis.pdf
Ghosh, Amrit Raj (2018) INNATE IMMUNE REGULATION OF METABOLIC SYNDROME. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/2767/