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Antioxidative and anti-inflammatory pyranoids and isochromenyl analogues from Corbiculid bivalve clam, Villorita cyprinoides

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Relation http://eprints.cmfri.org.in/12664/
 
Title Antioxidative and anti-inflammatory pyranoids and isochromenyl analogues
from Corbiculid bivalve clam, Villorita cyprinoides
 
Creator Joy, Minju
Chakraborty, Kajal
 
Subject Bioactive compound
Clam
 
Description Bivalve black clam, Villorita cyprinoides is traditional seafood in Southwestern coast of Arabian Sea. In this study,
bioactivity-guided purification of ethyl acetate:methanol extract of black clam was carried out. Two irregular
meroterpenoids {tetrahydro-3-methoxy-5-((E)-8,12-dimethyloct-8-enyl)-pyran-2-one (1) and dihydro-5-(8-
(9,12-dihydro-8-methyl-11-propyl-2H-pyran-8-yl)-ethyl)-furan-2(3H)-one (2)} and two hexahydro-isochromenyl-meroterpenoids
(3–4) were identified. The structures were characterized by detailed spectroscopy
and their antioxidant/anti-inflammatory potentials were evaluated. Compound 2 registered significantly greater
2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability (IC50 < 0.65 mg/mL) than other analogues
(IC50 ≥0.70 mg/mL). Ferrous ion (Fe2+) chelating ability was higher for 1–2 (IC50 ∼0.84 mg/mL) than α-
tocopherol (IC50 0.89 mg/mL). The 5-lipoxygenase inhibitory potential of furano-meroterpenoid analogue, 2
(IC50 0.76 mg/mL) was greater than other compounds (IC50 > 0.90 mg/mL). An optimum hydrophobic-hydrophilic
balance of furano-meroterpenoid and lesser steric bulk manifested towards its greater bioactivities compared
to other compounds. These anti-inflammatory and antioxidant leads could be used as potential functional
food components.
 
Publisher Elsevier
 
Date 2018
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/12664/1/Minju%20Joy_Kajal%20Chakraborty_2018_Antioxidative%20and%20anti-inflammatory%20pyranoids%20and%20isochromenyl%20analogues%20from%20Corbiculid%20bivalve%20clam%20Villorita%20cyprinoides_Food%20Chemistry.pdf
Joy, Minju and Chakraborty, Kajal (2018) Antioxidative and anti-inflammatory pyranoids and isochromenyl analogues from Corbiculid bivalve clam, Villorita cyprinoides. Food Chemistry, 251. pp. 125-134.