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Antioxidant and anti-inflammatory oxygenated meroterpenoids from the thalli of red seaweed Kappaphycus alvarezii

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Relation http://eprints.cmfri.org.in/12979/
https://link.springer.com/article/10.1007/s00044-018-2210-0
https://doi.org/10.1007/s00044-018-2210-0
 
Title Antioxidant and anti-inflammatory oxygenated meroterpenoids
from the thalli of red seaweed Kappaphycus alvarezii
 
Creator Chakraborty, Kajal
Makkar, Fasina
 
Subject Bioactive compound
Seaweed
 
Description Three antioxidant and anti-inflammatory oxygenated meroterpenoids, 1-(3-methoxypropyl)-2-propylcyclohexane (C13) (1),
3-(methoxymethyl)heptyl 3-(cyclohex-3-enyl) propanoate (C18) (2), and 2-ethyl-6-(4-methoxy-2-((2-oxotetrahydro-2Hpyran-
4-yl)methyl)butoxy)-6-oxohexyl 5-ethyloct-4-enoate (C29) (3) were purified from the methanol:ethyl acetate fraction
of red seaweed Kappaphycus alvarezii (family Solieriaceae) collected from the Gulf-of-Mannar on the southeast coast of
peninsular India. The highly oxygenated C29 meroterpenoid 3 displayed potential antioxidative activities (IC50 < 0.35 mg/
mL) as evaluated by 2, 2’-azino-bis (3-ethylbenzothiazoline)-6-sulphonic acid and 1, 1-diphenyl-2-picryl-hydrazil free
radical scavenging assays. The compound 3 displayed potential in vitro inhibitory activities towards pro-inflammatory 5-
lipoxidase (IC50 1.04 mg/mL), which indicated its potential anti-inflammatory properties against inducible inflammatory
mediators causing an inflammatory response. Structure-activity relationship analyses displayed the functional roles of
lipophilic-hydrophobic characteristics and electronic parameter to determine its potential anti-inflammatory activity in terms
of inhibiting inducible inflammatory cyclooxygenase and lipoxidase.
 
Date 2018
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/12979/1/Kajal%20Chakraborty_2018_Medicinal%20Chemistry%20Research_Antioxidant%20and%20anti-inflammatory%20oxygenated%20meroterpenoids%20from%20the%20thalli%20of%20red%20seaweed%20Kappaphycus%20alvarezii.pdf
Chakraborty, Kajal and Makkar, Fasina (2018) Antioxidant and anti-inflammatory oxygenated meroterpenoids from the thalli of red seaweed Kappaphycus alvarezii. Medicinal Chemistry Research, 27 (8). pp. 2016-2026.