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Elucidation Of Differential Role Of A Subunit Of RNA Polymerase II, Rpb4 In General And Stress Responsive Transcription In Saccharomyces Cerevisiae

Electronic Theses of Indian Institute of Science

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Title Elucidation Of Differential Role Of A Subunit Of RNA Polymerase II, Rpb4 In General And Stress Responsive Transcription In Saccharomyces Cerevisiae
 
Creator Gaur, Jiyoti Verma
 
Subject RNA Polymerase II (Pol II)
RNA Transcription
Saccharomyces Cerevisiae
Eukaryotes - Transcription
RPB4 Gene - Transcription
Genes - Transcription
Rpb4
Rpb7
Transcription Elongation
Pseudohyphal Growth
Pseudohyphal Morphogenesis
Biochemical Genetics
 
Description RNA polymerase II (Pol II) is the enzyme responsible for the synthesis of all mRNAs in eukaryotic cells. As the central component of the eukaryotic transcription machinery, Pol II is the final target of regulatory pathways. While the role for different Pol II associated proteins, co-activators and general transcription factors (GTFs) in regulation of transcription in response to different stimuli is well studied, a similar role for some subunits of the core Pol II is only now being recognized. The studies reported in this thesis address the role of the fourth largest subunit of Pol II, Rpb4, in transcription and stress response using Saccharomyces cerevisiae as the model system. Rpb4 is closely associated with another smaller subunit, Rpb7 and forms a dissociable complex (Edwards et al., 1991). The rpb4 null mutant is viable but is unable to survive at extreme temperatures (>34ºC and
 
Contributor Sadhale, Parag
 
Date 2010-09-14T06:07:19Z
2010-09-14T06:07:19Z
2010-09-14
2008-02
 
Type Thesis
 
Identifier http://etd.iisc.ernet.in/handle/2005/866
 
Language en_US
 
Relation G22324