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Molecular Genetic Studies On Pre-mRNA Splicing Factors Of Fission And Budding Yeasts

Electronic Theses of Indian Institute of Science

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Field Value
 
Title Molecular Genetic Studies On Pre-mRNA Splicing Factors Of Fission And Budding Yeasts
 
Creator Khandelia, Piyush
 
Subject mRNA Splicing
Yeasts
Molecular Genetics
Spliceosome
Yeast Ceflp-Associated Protein Complex
Fission Yeast - Mutation
SpSlu7
SpPrp18
Biochemical Genetics
 
Description Nuclear pre-mRNA splicing proceeds via two mechanistically conserved consecutive trans-esterification reactions catalyzed by the spliceosome. The ordered coalescence of spliceosomal snRNPs and splicing factors on the pre-mRNA, coupled with essential spliceosomal rearrangements poise the splice-sites in proximity for the two catalytic reactions, ensuring intron removal and exon ligation to yield functional mRNA (reviewed in Will and Lührmann, 2006).
Scope of the study
The S. cerevisiae splicing factors Prp18 and Slu7 and their human homologs function during second catalytic reaction. In S. cerevisiae, Slu7 is essential, whereas Prp18 is dispensable at temperatures
 
Contributor Vijayraghavan, Usha
 
Date 2010-10-05T05:16:51Z
2010-10-05T05:16:51Z
2010-10-05
2008-04
 
Type Thesis
 
Identifier http://etd.iisc.ernet.in/handle/2005/899
 
Language en_US
 
Relation G22337