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Classification of Marine Natural Products - Chemistry and Bioactivity

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Relation http://eprints.cmfri.org.in/13021/
 
Title Classification of Marine Natural Products - Chemistry and Bioactivity
 
Creator Chakraborty, Kajal
Salas, Soumya
Joy, Minju
Francis, Prima
Dhara, Subhajit
Antony, Tima
 
Subject Bioactive compounds
 
Description Enthusiasm of the scientific community towards the discovery of new drug leads from
marine habitats is unquenchable. Marine natural products have been recognized as a source
of highly desirable chemodiversity to support drug discovery and pharmacology applications
by the diverse chemical features and the wide range of biological activities possessed by
them. According to the latest review by Blunt et a,l., 1378 new compounds were isolated
from marine organisms in 2014 compared with 332 in 1984 (Blunt et al., 2016; Faulkner,
1994). Marine flora and fauna play a momentous role as a foundation of new molecular
entity. Over 5 million species of the world in about 30 different phyla reside in the oceans.
Because of the diversities of marine organism and habitats, marine natural products enfold
a wide variety of chemical classes, including Terpenes, Shikimates, Polyketides, Acetogenins,
Peptides, and Alkaloids of varying structures and multitude of compounds of mixed
biosynthesis. These natural products are secondary metabolites and enhance survival fitness
and may serve as chemical weapons used against bacteria, fungi, viruses and small or large
animals. A good number of the natural products of interest to the pharmaceutical industry
are secondary metabolites and several such compounds, derived from marine organisms,
have been in clinical trials as experimental drugs. Over the past 50 years, numerous novel
compounds have been isolated from marine flora and fauna having biological activities
such as antibacterial, antiviral, antitumor, antiparasitic, anticoagulants, antimicrobial, antiinflammatory
and cardiovascular compounds.
 
Date 2018
 
Type Conference or Workshop Item
NonPeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/13021/1/Winter%20School_Recent%20Advances_Bioactive%20compounds_Chapter%204.pdf
Chakraborty, Kajal and Salas, Soumya and Joy, Minju and Francis, Prima and Dhara, Subhajit and Antony, Tima (2018) Classification of Marine Natural Products - Chemistry and Bioactivity. In: Winter School on “Recent advances in bioactive compounds from marine organisms and development of high value products for health management, ICAR-Central Marine Fisheries Research Institute, Kochi.