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<p class="TitleMain">Antimycobacterial activity of linoleic acid and oleic acid obtained from the hexane extract of the seeds of <em>Mesua ferrea</em> L. and their <em>in silico</em> investigation</p>

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Title Statement <p class="TitleMain">Antimycobacterial activity of linoleic acid and oleic acid obtained from the hexane extract of the seeds of <em>Mesua ferrea</em> L. and their <em>in silico</em> investigation</p>
 
Added Entry - Uncontrolled Name Kalita, Ranjan Dutta; Tezpur University, Tezpur-784028, Assam, India
Hussain, Iftikar ; Tezpur University, Tezpur-784028, Assam, India
Deka, Ramesh C; Tezpur University,Tezpur-784028, Assam, India
Buragohain, Alak Kumar; Tezpur University, Tezpur-784028, Assam, India
CSIR
 
Uncontrolled Index Term Medicinal Plants, Natural Products
Antituberculosis; Cytotoxicity; Docking; Medicinal plants; Mesua ferrea L
 
Summary, etc. <p class="Abstract" style="text-align: justify;">Tuberculosis is responsible for about 8 million deaths worldwide annually. The emergence of multidrug-resistant and extensively drug-resistant strains urgently requires the development of new drugs against tuberculosis. Drug discovery from plants against tuberculosis is an exciting area for exploration. In the present study, the fatty acids- linoleic and oleic acids isolated and identified from the seeds of the plant <em>Mesua ferrea </em>L. exhibited antimycobacterial activity. The analysis was done using Gas Chromatography-Mass Spectrometry and supplementary information was obtained using fourier transform-infra red and <sup>1</sup>H and <sup>13</sup>C nuclear magnetic resonance. The minimum inhibitory concentration of the purified fraction containing both the compounds was found to be 78 µg/mL. <em>In silico</em> molecular docking studies against the target proteins GlfT2, Inh A and mtKasB of <em>Mycobacterium tuberculosis </em>revealed high scores for both the compounds. Cytotoxicity studies of the compounds revealed no toxicity and high antioxidant activity was observed.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2018-09-25 12:39:37
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/14354
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 9, ##issue.no## 2 (2018): June, 2018
 
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