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Statistical Designs for Microarray Experiments

KrishiKosh

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Field Value
 
Title Statistical Designs for Microarray Experiments
PH D
 
Creator SUKANTA DASH
 
Contributor Rajender Parsad
 
Subject 2-Colour Microarray experiments, Row-column designs, A-efficiency, Defficiency, Robustness
 
Description T-8703
A general method of construction of efficient row-column designs with two
rows useful for 2-colour single factor microarray experiments has been developed. Lower
bounds to A- and D- efficiencies of the designs obtained through the proposed method of
construction have been computed and compared with those of best available designs in
the literature under a fixed effects model. The comparison of lower bounds to A- and Defficiencies
of the designs obtained for 3 v 10,v b v(v 1) / 2, , 11 v 35,b v
and (v, b) = (11,12), (11,13), (12,13), (12,14), (13,14), (13,15), (13,16), where v is the
number of treatments and b is the number of columns or arrays has also been made with
those of best available designs under a mixed effects model. Robustness aspects of
optimal / efficient designs has been investigated under a mixed effects model for different
value of ρ (a function of inter and intra block variances). Several designs have been
obtained that are more efficient under mixed effects model as compared to the best
available designs. A procedure of obtaining efficient row-column designs for single
factor microarray experiments in the above parametric range, along with their
efficiencies, has been developed using C# programming language with ASP.NET
platform.
 
Date 2016-09-06T17:24:02Z
2016-09-06T17:24:02Z
2012
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/75750
 
Format application/pdf
 
Publisher IARI, INDIAN AGRICULTURAL STATISTICS RESEARCH INSTITUTE