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Chronic toxicological studies on the interaction of flubendiamide and lead following oral administration in buffalo calves

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Title Chronic toxicological studies on the interaction of flubendiamide and lead following oral administration in buffalo calves
 
Creator Ranjan, Amita
 
Contributor Dumka, V. K.
 
Subject Buffalo- calves
Flubendiamide
Interaction
Lead
Toxicity
 
Description Toxic effects of flubendiamide, lead and their interaction were studied in buffalo calves.
Flubendiamide administration (@ 0.024 mg/kg/day for 90 days) produced clinical signs including dullness,
depression and poor weight gain. ALT, AST, BUN and AKLP increased significantly. Haematological
parameters and blood mineral profile did not differ significantly. Increase in LPO, catalase and GST and
decrease in SOD, catalase, GSH, GPx, GR, G6PD and TAA were observed, suggesting compromise in
antioxidant defense. ALAD activity in blood declined marginally, but GFAP and aspartic acid (AA) in CSF
increased. T3 and T4 declined, but TSH did not differ significantly. In lead acetate (9.2 mg/kg/day for 90 days)
exposed calves ALT, AST, AKLP, GGTP, BUN and creatinine increased, but Hb and PCV decreased
significantly. Significant increase in LPO and decline in antioxidant enzymes activities were noted. Significant
decline in Ca, Fe, Zn and Cu and ALAD activity in blood were observed. In CSF, GFAP increased, while AA
did not change significantly. T3 and T4 decreased, but TSH increased. Animals exposed to both flubendiamide
and Pb revealed changes in biochemical profile similar to Pb exposed group. Haematological and oxidative
stress parameters also revealed similar pattern of change. In CSF, GFAP were lower, while AA was higher. T3 and T4 were higher, but TSH was lower than Pb alone exposed animals. Present study revealed hepatotoxic, nephrotoxic and neurotoxic potential of Pb and flubendiamide, possibly associated with oxidative stress. Flubendiamide and Pb had additive effects on changes in biochemical and oxidative stress parameters.
 
Date 2016-08-26T16:39:24Z
2016-08-26T16:39:24Z
2014-10-10
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/73990
 
Language en
 
Format application/pdf