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Synthesis and Biological Activity of Novel Azomethine Compounds

KrishiKosh

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Title Synthesis and Biological Activity of Novel Azomethine Compounds
 
Creator Tilak Mondal
 
Contributor Rajesh Kumar
 
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Description T-8488
Schiff bases are well known for their wide spectrum of biological activities.
Recently, Schiff bases have been discovered as excellent fungicide and nitrification
inhibitor. To optimize the structure to improve the bioactivity of azomethine (Schiff
Base) derivatives, 23 novel Schiff bases derived from 2,4,5-trichloroaniline were
synthesized and characterized using spectral techniques. These molecules were further
explored for their antifungal activity against Rhizoctonia bataticola and Sclerotium rolfsii
and nitrification inhibitory activity under laboratory conditions. For the nitrification
inhibition, compounds were tested at three doses (1, 5 and 10%) along with reference
inhibitors, N-Serve, Dicyandiamide and urea for 28 days incubation period. Significantly
higher ammonium-N and less nitrate-N were observed with all title compounds as
compared to urea alone. No nitrite-N was observed in all the treatments. All test
compounds were highly effective as nitrification inhibitors. The potent compounds
emerged from the series were (2,4-dimethoxybenzylidene)-(2,4,5-trichlorophenyl)-amine
(C23) (4-isopropylbenzylidene)-(2,4,5-trichlorophenyl)-amine (C21) and (3,4,5-
trimethoxybenzylidene)-(2,4,5-trichlorophenyl) amine (C3). In case of antifungal activity
all test compounds were highly effective against both the pathogenic fungi except (2-
nitrobenzylidine)-(2,4,5-trichlorophenyl) amine. In general, test compounds were more
effective against R. bataticola (ED50, 9.4-66.2 μg/ml) as compared to S. rolfsii (ED50,
10.6-117.1 μg/ml). The maximum antifungal activity was observed with compound,
(3,4,5-trimethoxybenzylidine)-(2,4,5-trichlorophenyl) amine (C3) with ED50 9.4 μg/ml
against R. Bataticola. On the other hand, (4-tert-butyl-benzylidine)-(2,4,5-
trichlorophenyl)-amine (C-15) was best against S. rolfsii with ED50, 10.6 μg/ml with high
unit activity against R. bataticola also (ED50, 11.4 μg/ml).
 
Date 2016-11-25T13:20:28Z
2016-11-25T13:20:28Z
2011
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/87505
 
Format application/pdf
 
Publisher IARI, DIVISION OF AGRICULTURAL CHEMICALS