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FORMULATION, CHARACTERIZATION, IN-VIVO & EX-VIVO EVALUATION OF GELATIN NANOPARTICLES ENCAPSULATING AN ANTI-INFLAMMATORY AND AN ANTI-BACTERIAL DRUG TO CONTROL PATHOPHYSIOLOGICAL DISORDER(S) USING APPROPRIATE ANIMAL MODELS

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Title FORMULATION, CHARACTERIZATION, IN-VIVO & EX-VIVO EVALUATION OF GELATIN NANOPARTICLES ENCAPSULATING AN ANTI-INFLAMMATORY AND AN ANTI-BACTERIAL DRUG TO CONTROL PATHOPHYSIOLOGICAL DISORDER(S) USING APPROPRIATE ANIMAL MODELS
 
Creator MAHOR, ALOK
 
Contributor Prajapati, Sunil Kumar
 
Subject null
 
Description The present investigation involves the preparation of two gelatin nanoparticulate
formulations laden with Naproxen, an anti-inflammatory drug (NGP1) and Moxifloxacin,
an anti-bacterial drug (MGP1). The nanoparticulate formulations were prepared by a
modified two step desolvation technique upon varying the crosslinking ratio with drug and
polymer and were assessed for their analgesic, anti-inflammatory and anti-bacterial
activities. Gelatin being biodegradable and non-toxic it is the selected for the formulation
of nanoparticles loaded with Naproxen and Moxifloxacin. Naproxen, a well-known
NSAID, has been selected for its excellent analgesic and anti-inflammatory properties.
Moxifloxacin, an anti-bacterial drug has proven its efficacy in controlling the microbial
growth but its use in opthalmic preparations is limited. DSC thermograms reported
molecular level dispersion of drug in the nanoparticles whilst FTIR studies exhibited no
drug-polymer interactions. Particles of nanometer size range were formulated 177±2.17 nm
and 175 ± 1.11 nm for Naproxen and Moxifloxacin loaded Gelatin nanoparticles) and the
size distribution was monodisperse in the entire prepared batches for both formulations
with low polydispersity index. Entrapment efficiency of the nanoformulations was 65%
and 57% for NGP1 and MGP1. Both the formulations displayed an initial burst release
followed by controlled release of the drug, the Korsmeyer-Peppas showed better linearity
and the formulations displayed non-Fickian drug release pattern. NGP1 exhibited
significant (P
 
Date 2018-03-13T06:20:50Z
2018-03-13T06:20:50Z
2017
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/5810041720
 
Language en
 
Format application/pdf
 
Publisher Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Naini, Allahabad - 211007