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Synthesis and Biological Evaluation of Some Novel 1,2,4-Triazoles

KrishiKosh

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Title Synthesis and Biological Evaluation of Some Novel 1,2,4-Triazoles
 
Creator Kumar, Ajay
 
Contributor KASHAW, VARSHA
VERMA, AMITA
 
Subject 1,2,4- triazoles, heterocyclic, antitubercular, antibacterial, antifungal
 
Description Thesis titled “Synthesis and Biological Evaluation of Some Novel 1,2,4-Triazoles” submitted in partial fulfillment of the requirements for the award of the degree of Doctor of Philosophy in Pharmaceutical Sciences by Ajay Kumar.
Tuberculosis (TB) is a major public health problem in India. India accounts for one-fifth
of the global TB incident cases. Each year nearly 2 million people in India develop TB,
of which around 0.87 million are infectious cases. 1,2,4-triazole nucleus is present in
various chemotherapeutic agents such as fluconazole, terconazole, itraconazole,
trazodone etc. Compounds containing heterocyclic ring are not only essential to life but
also shows a wide variety of pharmacological activity. Amongst the five-membered
nitrogen containing heterocycles, the position of nitrogen atoms at 1, 2 and 4 activates the
ring. 1,2,4-Triazole and its derivatives represent one of the most biologically active
classes of compounds, possessing a wide spectrum of activities Various 1,2,4-triazole
derivatives have been reported to possess diverse types of biological properties such as
antitubercular, anticonvulsant, antibacterial, antifungal, anti-inflammatory,
antihypertensive, antiviral, antileishmanial, and antimigraine activities. Therefore, the
present research was designed to synthesize some novel 1,2,4-Triazoles, their
characterization and evaluation for antitubercular, antibacterial and antifungal activity.
Aims and Objectives: The present research is designed to Synthesize novel 1,2,4-
Triazoles, their characterization and biological evaluation for antitubercular, antibacterial
and antifungal activity.
 
Date 2016-12-19T12:54:40Z
2016-12-19T12:54:40Z
2016
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/91002
 
Language en
 
Format application/pdf
 
Publisher Sam Higginbottom Institute of Agriculture, Technology & Sciences (SHIATS)