ICAR Research Data Repository for Knowledge Management
Synthesis of some heterocyclic compounds using ecofriendly conditions and their bioevaluation
KrishiKosh
View Archive Info| Field | Value | |
| Title |
Synthesis of some heterocyclic compounds using ecofriendly conditions and their bioevaluation
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| Creator |
Suprita
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| Contributor |
Rajvir Singh
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| Subject |
null
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| Description |
Coumarins, Chalcones, Pyrazoles and Imidazoles are versatile classes of heterocycles and intermediates for the preparation of other organic compounds due to their variety of biological activities. For the preparation of these compounds and their derivatives, different organic solvents and reagents are being used which are quite hazardous to environment and human health due to their volatile nature. Since last few years attempts are being made for ecofriendly synthesis viz. microwave irradiation synthesis and synthesis by grinding methods. Therefore an attempt has been made to synthesize above mentioned classes of compounds by grinding methods, aqua mediated methods and microwave assisted methods. These compounds were characterized by spectroscopic techniques viz. 1HNMR, IR, Elemental analysis and other analytical data. Structure of the compounds were found identical in all methods of synthesis i.e. conventional, grinding methods, aqua mediated methods and microwave assisted method. Synthesized compounds were screened for their antifungal activity by poison food technique at four different concentrations. Compounds 33 and 93 were found more active against the tested fungi Rhizoctonia solani and Aspergillus niger with EC50 values 53.13 and 56.52μg/ml respectively. |
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| Date |
2018-10-18T07:14:24Z
2018-10-18T07:14:24Z 2018 |
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| Type |
Thesis
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| Identifier |
http://krishikosh.egranth.ac.in/handle/1/5810081726
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| Language |
en
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| Format |
application/pdf
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| Publisher |
CCSHAU
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