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Pathological and immunohistochemical studies on canine mammary tumours with emphasis on diagnostic and prognostic aspects

KrishiKosh

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Title Pathological and immunohistochemical studies on canine mammary tumours with emphasis on diagnostic and prognostic aspects
 
Creator Gupta, Kuldeep
 
Contributor Sood, N. K.
 
Subject Canine mammary tumour
clinical biochemistry
cytopathology
hematology
histopathology
immunohistochemistry
molecular subtypes
serum hormones
survival analysis
 
Description The present study conducted on 51 cases of canine mammary tumour(s)
(CMT) revealed 56 tumours (55 malignant + 1 benign), affecting 50 females and 1
male dog. The overall incidence of CMT was 46.79 % of all canine tumours, with a
median age affected as 9.0 years and maximum involvement of the fifth pair of glands
and the higher predisposition in heavier breeds. The hematological and biochemical
values in the different individual dogs varied significantly, but among different
histological groups, only non-significant variations were recorded. However, the
mean serum values of estradiol and progesterone were markedly higher in CMT. A
vast majority of CMT were malignant (98.21%) with pulmonary metastasis (25.49%)
and were classified as carcinomas (45.45 %), carcinosarcoma (30.91%), sarcomas
(20.00%) and others (TVT; 3.63%). A good correlation (95.74%) of cytology with
histopathology with a sensitivity of 97.22% in diagnosing CMT were also recorded.
Immunohistochemical studies using a panel of 22 diagnostic and prognostic markers
revealed the significance of intermediate filaments (cytokeratins, vimentin and smooth
muscle actin), and p63 in confirming and improvising the histological diagnoses,
whereas, Her 2 and EGFR as prognostic markers of CMT. Based upon
immunohistochemical profiling, the tumours were classified into molecular subtypes
viz, luminal B (34.70%), basal (28.57%), luminal A (20.41%) and Her 2
over-expressing and unclassified (8.16%) each, respectively. The significance of
inflammation, mast cells and micro-calcification in CMT was highlighted. The follow
up studies for about 2 years, using Kaplan- Meier analysis, revealed the mean survival
of dogs with CMT as 3.73 and 13.40 months, without and with censoring,
respectively.
 
Date 2016-07-21T10:12:02Z
2016-07-21T10:12:02Z
2011-02-11
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/69089
 
Language en
 
Format application/pdf