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FUNCTIONAL SIGNIFICANCE OF HOST AND VIRAL GENES INVOLVED IN STRESS RESPONSES DURING PAPAYA RINGSPOT VIRUS (PRSV) INFECTION

KrishiKosh

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Title FUNCTIONAL SIGNIFICANCE OF HOST AND VIRAL GENES INVOLVED IN STRESS RESPONSES DURING PAPAYA RINGSPOT VIRUS (PRSV) INFECTION
Ph.D
 
Creator SAHANA, NANDITA
 
Contributor Shelly Praveen
 
Subject sowing, diseases, fungi, vegetables, seed treatment, physical control, storage, land resources, germinability, developmental stages
 
Description T-8844
Plant viruses invade host cells and utilize the cellular pathways of the host to
support various aspects of their infection cycle. To achieve these goals viruses must
utilize the multi faceted defense mechanism of the host to make them susceptible for
virus establishment. Hence the functional significance of viral proteins in
modulating host defense responses is interesting to study. The main focus in the
present study was the functional significance of Papaya ringspot virus (PRSV)
derived protein Helper component Proteinase (HcPro) during viral infection in host.
The present study highlights the essential role of Ubiquitin/26S proteasome system
in plant defense responses during PRSV infection in papaya. Also altered expression
was observed for microRNAs involved in plant defense and hormonal signaling in
the papaya leaf tissues, suggesting their probable role in symptom development.
Further the study emphasized the importance of viral protein HcPro in modulating
catalytic activities of 20S core of proteasomal complex, in support of virus
accumulation through molecular interaction with proteasomal subunit 1 and
proteasomal subunit 5. Besides altering 20S proteasomal catalytic activities, HcPro
was also found to play an important role in small RNA biogenesis, by its capacity to
bind double stranded small RNAs, leading to systemic suppression of RNA
silencing. The two well characterized domains at N terminal and the central region
of the HcPro protein were found to be associated with these activities respectively.
Taken together the present study reveals the critical importance of PRSV-HcPro in
modulating plant defense responses like RNAi and proteasomal pathways in favour
of virus accumulation.
 
Date 2016-06-22T10:41:04Z
2016-06-22T10:41:04Z
2013
 
Type Thesis
 
Identifier http://krishikosh.egranth.ac.in/handle/1/67655
 
Format application/pdf
 
Publisher IARI,DIVISION OF BIOCHEMISTRY