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Associations of polymorphisms in the cytokine genes IL1β (rs16944), IL6 (rs1800795), IL12b (rs3212227) and growth factor VEGFA (rs2010963) with anthracosilicosis in coal miners in Russia and related genotoxic effects

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Title Associations of polymorphisms in the
cytokine genes IL1β (rs16944), IL6 (rs1800795),
IL12b (rs3212227) and growth factor VEGFA
(rs2010963) with anthracosilicosis in coal miners
in Russia and related genotoxic effects
 
Creator Volobaev, Valentin P.
Larionov, Aleksey V.
Kalyuzhnaya, Ekaterina E.
Serdyukova, Ekaterina S.
Yakovleva, Svetlana
Druzhinin, Vladimir G.
Babich, Olga O.
Hill, Elena G.
Semenihin, Victor A.
Panev, Nikolay I.
Minina, Varvara I.
Sivanesan, Saravana Devi
Naoghare, Pravin
Silva, Juliana da
Barcelos, Gustavo R. M.
Prosekov, Alexander Y.
 
Subject Environmental Health
 
Description Anthracosilicosis (AS), a prevalent form of pneumoconiosis among coal miners, results from the
accumulation of carbon and silica in the lungs from inhaled coal dust. This study investigated
genotoxic effects and certain cytokine genes polymorphic variants in Russian coal miners with
АS. Peripheral leukocytes were sampled from 129 patients with AS confirmed by X-ray and
tissue biopsy and from 164 asymptomatic coal miners. Four single-nucleotide polymorphisms
were genotyped in the extracted DNA samples: IL1β T-511C (rs16944), IL6 C-174G (rs1800795),
IL12b A1188C (rs3212227) and VEGFA C634G (rs2010963). Genotoxic effects were assessed by the
analysis of chromosome aberrations in cultured peripheral lymphocytes. The mean frequency of
chromatid-type aberrations and chromosome-type aberrations, namely, chromatid-type breaks and
dicentric chromosomes, was found to be higher in AS patients [3.70 (95% confidence interval {CI},
3.29–4.10) and 0.28 (95% CI, 0.17–0.38)] compared to the control group [2.41 (95% CI, 2.00–2.82)and 0.09 (95% CI, 0.03–0.15)], respectively. IL1β gene T/T genotype (rs16944) was associated with
AS [17.83% in AS patients against 4.35% in healthy donors, odds ratio = 4.77 (1.88–12.15), P < 0.01].
A significant increase in the level of certain chromosome interchanges among AS donors is of
interest because such effects are typical for radiation damage and caused by acute oxidative
stress. IL1β T allele probably may be considered as an AS susceptibility factor among coal miners.
 
Publisher OUP
 
Date 2018
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/1189/1/Associations%20of%20polymorphisms.pdf
Volobaev, Valentin P. and Larionov, Aleksey V. and Kalyuzhnaya, Ekaterina E. and Serdyukova, Ekaterina S. and Yakovleva, Svetlana and Druzhinin, Vladimir G. and Babich, Olga O. and Hill, Elena G. and Semenihin, Victor A. and Panev, Nikolay I. and Minina, Varvara I. and Sivanesan, Saravana Devi and Naoghare, Pravin and Silva, Juliana da and Barcelos, Gustavo R. M. and Prosekov, Alexander Y. (2018) Associations of polymorphisms in the cytokine genes IL1β (rs16944), IL6 (rs1800795), IL12b (rs3212227) and growth factor VEGFA (rs2010963) with anthracosilicosis in coal miners in Russia and related genotoxic effects. Mutagenesis, 32 (2). pp. 129-135. ISSN 0267-8357, ESSN: 1464-3804
 
Relation https://academic.oup.com/mutage
http://neeri.csircentral.net/1189/