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Prediction of Antitubercular Peptides From Sequence Information Using Ensemble Classifier and Hybrid Features.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Prediction of Antitubercular Peptides From Sequence Information Using Ensemble Classifier and Hybrid Features.
 
Creator Usmani, Salman Sadullah
Bhalla, Sherry
Raghava, G.P.S.
 
Subject QR Microbiology
 
Description Tuberculosis is one of the leading cause of death worldwide, particularly due to evolution of drug resistant strains. Antitubercular peptides may provide an alternate approach to combat antibiotic tolerance. Sequence analysis reveals that certain residues (e.g., Lysine, Arginine, Leucine, Tryptophan) are more prevalent in antitubercular peptides. This study describes the models developed for predicting antitubercular peptides by using sequence features of the peptides. We have developed support vector machine based models using different sequence features like amino acid composition, binary profile of terminus residues, dipeptide composition. Our ensemble classifiers that combines models based on amino acid composition and N5C5 binary pattern, achieves highest Acc of 73.20% with 0.80 AUROC on our main dataset. Similarly, the ensemble classifier achieved maximum Acc 75.62% with 0.83 AUROC on secondary dataset. Beside this, hybrid model achieves Acc of 75.87 and 78.54% with 0.83 and 0.86 AUROC on main and secondary dataset, respectively. In order to facilitate scientific community in designing of antitubercular peptides, we implement above models in a user friendly webserver (http://webs.iiitd.edu.in/raghava/antitbpred/).
 
Publisher Frontiers Media S.A
 
Date 2018-08-28
 
Type Article
PeerReviewed
 
Relation https://www.frontiersin.org/articles/10.3389/fphar.2018.00954/full
http://crdd.osdd.net/open/2145/
 
Identifier Usmani, Salman Sadullah and Bhalla, Sherry and Raghava, G.P.S. (2018) Prediction of Antitubercular Peptides From Sequence Information Using Ensemble Classifier and Hybrid Features. Frontiers in pharmacology, 9. p. 954. ISSN 1663-9812