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Host heme oxygenase-1: Friend or foe in tackling pathogens?

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Host heme oxygenase-1: Friend or foe in tackling pathogens?
 
Creator Singh, Nisha
Ahmad, Zeeshan
Baid, Navin
Kumar, Ashwani
 
Subject QR Microbiology
 
Description Infectious diseases are a major challenge in management of human health worldwide. Recent literature suggests that host immune system could be modulated to ameliorate the pathogenesis of infectious disease. Heme oxygenase (HMOX1) is a key regulator of cellular signaling and it could be modulated using pharmacological reagents. HMOX1 is a cytoprotective enzyme that degrades heme to generate carbon monoxide (CO), biliverdin, and molecular iron. CO and biliverdin (or bilirubin derived from it) can restrict the growth of a few pathogens. Both of these also induce antioxidant pathways and anti-inflammatory pathways. On the other hand, molecular iron can induce proinflammatory pathway besides making the cellular environment oxidative in nature. Since microbial infections often induce oxidative stress in host cells/tissues, role of HMOX1 has been analyzed in the pathogenesis of number of infections. In this review, we have described the role of HMOX1 in pathogenesis of bacterial infections caused by Mycobacterium species, Salmonella and in microbial sepsis. We have also provided a succinct overview of the role of HMOX1 in parasitic infections such as malaria and leishmaniasis. In the end, we have also elaborated the role of HMOX1 in viral infections such as AIDS, hepatitis, dengue, and influenza. © 2018 IUBMB Life, 70(9):869-880, 2018.
 
Publisher Wiley
 
Date 2018-05-14
 
Type Article
PeerReviewed
 
Relation https://doi.org/10.1002/iub.1868
http://crdd.osdd.net/open/2163/
 
Identifier Singh, Nisha and Ahmad, Zeeshan and Baid, Navin and Kumar, Ashwani (2018) Host heme oxygenase-1: Friend or foe in tackling pathogens? IUBMB life, 70 (9). pp. 869-880. ISSN 1521-6551