<p style="text-align: justify;"><strong>Bioactive metabolites from the ruminal bacterium<em> Enterobacter amnigenus</em></strong><strong> ZIH</strong></p>
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Title Statement |
<p style="text-align: justify;"><strong>Bioactive metabolites from the ruminal bacterium<em> Enterobacter amnigenus</em></strong><strong> ZIH</strong></p> |
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Added Entry - Uncontrolled Name |
El Euch, Imene Zendah; Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany Shaaban, Khaled A; Center for Pharmaceutical Research and Innovation, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States Riaz, Naheed ; Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan Bahi, Muhammad ; Chemistry Department, Faculty of Mathematics and Natural Sciences, University of Syiah Kuala, Kampus Darussalam, Banda Aceh 23111, Indonesia Shaaban, Mohamed ; Chemistry of Natural Compounds Department, Division of Pharmaceutical Industries, National Research Centre, El-Behoosst. 33, Dokki-Cairo 12622, Egypt Institute of Organic and Biomolecular Chemistry, Göttingen |
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Uncontrolled Index Term |
bioassay-guided fractionation, chromatographic purification, bioactive metabolites, ruminal bacteria Biological activities; Brevinic acid; Butyl-glucoside; Enterobacter amnigenus ZIH; Ruminal bacteria |
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Summary, etc. |
<p style="text-align: justify;">Bioassay-guided fractionation and chromatographic purification of the crude extract of ruminal bacterium <em>Enterobacter amnigenus</em> ZIH (isolated from cattle) produce one new microbial product:butyl-a-D-glucopyranoside together with eleven known compounds including (<em>S</em>)-brevinic acid, 3-(hydroxyacetyl)-indole, <em>N<sub>ß</sub></em>-acetyltryptamine, tyrosol, phenol, tryptophol, indole-3-lactic acid, uracil, adenine and two diketopiperazines <em>cyclo</em>-(Phe, Pro) and <em>cyclo</em>-(Leu, Pro). The complete NMR assignments of butyl-a-D-glucopyranoside was done - using different spectroscopic (<sup>1</sup>H, <sup>13</sup>C, <sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) and spectrometric methods (ESI-MS, HRESI-MS). Compounds 1a and 2 reported for the first time from a natural source. The bacterial extract exhibited high cytotoxicity against brine shrimp and moderate antimicrobial activity against a diverse set of pathogenic bacteria strains.</p> |
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Publication, Distribution, Etc. |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] 2019-03-25 13:21:29 |
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Electronic Location and Access |
application/pdf http://op.niscair.res.in/index.php/IJNPR/article/view/18300 |
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Data Source Entry |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 9, ##issue.no## 3 (2018): September, 2018 |
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en |
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