<p><strong></strong><strong>Optimization of microwave-assisted extraction of bioactive polyphenolic compounds from <em>Marsilea quadrifolia </em>L. using RSM and ANFIS modelling</strong></p>
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Title Statement |
<p><strong></strong><strong>Optimization of microwave-assisted extraction of bioactive polyphenolic compounds from <em>Marsilea quadrifolia </em>L. using RSM and ANFIS modelling</strong></p> |
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Added Entry - Uncontrolled Name |
Chowdhury, Anindita ; Department of Chemical Engineering, Jadavpur University, Kolkata-700032, West Bengal Panneerselvam, Theivendren ; Department of Pharmaceutical Chemistry, Karavali College of Pharmacy, Vamanjoor, Near Reymond, Vamanjoor, Mangaluru-575028, Karnataka Kannan, Suthendran ; National Cyber Defence Research Center, Kalasalingam Academy of Research and Education, Krishnankoil 626126, Tamilnadu Bhattachejee, Chiranjib ; Department of Chemical Engineering, Jadavpur University, Kolkata-700032, West Bengal Somasundaram, Balasubramanian ; Sir CV Raman-KS Krishnan International Research Center, Kalasalingam Academy of Research and Education, Krishnankoil 626126, Tamilnadu Sankaranarayanan, Murugesan ; Department of Pharmacy, Birla Institute of Technology and Science, Pilani-333031, Rajasthan Baskararaj, Suraj ; Sir CV Raman-KS Krishnan International Research Center, Kalasalingam Academy of Research and Education, Krishnankoil 626126, Tamilnadu Kunjiappan, Selvaraj ; Sir CV Raman-KS Krishnan International Research Center, Kalasalingam Academy of Research and Education, Krishnankoil 626126, Tamilnadu Kalasalingam Academy of Research and Education, Krishnankoil, India |
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Uncontrolled Index Term |
bioactive compounds, pharmacology, antioxidant ANFIS; Antioxidant activity; CCRD; Marsilea quadrifolia L.; Polyphenolic compound; RSM. |
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Summary, etc. |
<p style="text-align: justify;">Extraction of bioactive compounds, rich in plant secondary metabolites as a form of polyphenolic compounds has gained utmost important in the food and pharmaceutical industries due to their antioxidant properties. Microwave-assisted extraction (MAE) was utilized for maximum extraction of bioactive polyphenolic compounds from <em>Marsilea quadrifolia </em>L. with consuming less toxic solvent. A central composite rotatable design (CCRD) based on response surface methodology (RSM) and adaptive neuro-fuzzy inference system (ANFIS) were followed to design and optimize the experimental parameters to get highest yield of bioactive polyphenolic compounds from <em>M. quadrifolia </em>L. The quantitative effects of experimental parameters such as methanol concentration (<em>X</em>1), microwave power (<em>X</em>2), irradiation temperature (<em>X</em>3) and irradiation time (<em>X</em>4) were investigated to obtain the maximum yields of total phenolic (TPC), total flavonoid contents (TFC) and antioxidant properties. The optimum conditions were observed at methanol concentration (<em>X</em>1= 87.5 %), microwave power (<em>X</em>2= 25 %), irradiation temperature (<em>X</em>3= 60 ºC) and irradiation time (<em>X</em>4= 15 min). Under these conditions, the highest yields of TPC (y1)= 693.28 mg gallic acid equivalents (GAE)/g), TFC (y2)= 84.86 mg rutin equivalents (RU)/g), % DPPHsc (y3)= 81.06 %, %ABTSsc (y4)= 71.34% and FRAP (y5)= 68.09 μg mol (Fe (II)/g) has been attained. Further, the experimental results were highly acknowledged with predicted values of RSM and ANFIS. The analysis of LC-ESI-MS spectrum confirmed 6 major bioactive compounds, namely, Betasitosterol, Tridecyliodide, 2,3,7,8 tetracholorodibenzofuaran, Chlorogenic acid, Pentachlorophenylacetate and Triacontyl hexacosanoate in the optimized extract of <em>M. quadrifolia </em>L. The optimized extract can be used as an alternative of synthetic antioxidants for product manufacturing in food and pharmaceutical industries.</p> |
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Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] 2019-03-25 13:21:29 |
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application/pdf http://op.niscair.res.in/index.php/IJNPR/article/view/20496 |
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Data Source Entry |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 9, ##issue.no## 3 (2018): September, 2018 |
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en |
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