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Evaluation of acute toxicity and intestinal transit time of <em>Croton tiglium </em>L. seeds

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Title Statement Evaluation of acute toxicity and intestinal transit time of <em>Croton tiglium </em>L. seeds
 
Added Entry - Uncontrolled Name Vekariya, Shweta R; Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar-361008, Gujarat
Taviad, Krushnkumar P; Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar-361008, Gujarat
Ranpariya, Nidhi ; Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar-361008, Gujarat,
Nariya, Mukesh ; Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar-361008, Gujarat
Acharya, R N; Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar-361008, Gujarat
Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat,India
 
Uncontrolled Index Term Acute toxicity, Croton tiglium, Intestinal transit, Jayapala, Shodhana.
 
Summary, etc. <p class="Abstract" style="text-align: justify;">The seeds of <em>Jayapala</em> (<em>Croton tiglium </em>L.) (Euphorbiaceae) is classified under <em>Upavisha </em>in classical texts of Ayurveda known for its purgative action and is being used in the management of several disorders. Ayurvedic Pharmacopoeia of India recommends its <em>Shodhana</em> prior to its internal administration. The present study was planned with an aim to evaluate the acute toxicity of raw and <em>Shodhita</em> seeds of <em>Croton tiglium</em> L. and intestinal transit time of <em>Shodhita</em> seeds on experimental animals. Acute oral toxicity study for Raw <em>J</em><em>ayapala </em>(RJ) and <em>Shodhita Jayapala</em> (SJ) seed sample were carried out following OECD guidelines. Rats were administered a single dose of 2000 mg/kg orally and then observed individually for the first 30 mins, then over a period of every 2 hours for 24 hours and at least once daily for 14 days. General behaviour, adverse effects and mortality were observed throughout the experimental period. Intestinal transit time in mice was carried out at the lower dose of 2.54 mg/kg and the higher dose of 7.61 mg/kg by adopting Kaolin expulsion test and latency of the onset of kaolin expulsion in faecal matter. The results showed that the raw <em>Jayapala</em> produced mortality in a single oral dose of 2000 mg/kg while <em>Shodhita Jayapala</em> did not <em>Jayapala</em> produce any <em>mortality</em> and toxicity except behavioural changes and diarrhoea at the same dose level. In kaolin expulsion test, <em>Shodhita</em> <em>Jayapala</em> produced marked increase in intestinal motility in mice among which higher dose of the drug was found better which was proved by fast clearance of kaolin in faecal pellet in comparison to control group. Oral acute toxicity study suggests that <em>Shodhana </em>(processing/purifying) process must be advocated for use of <em>Jayapala</em> to eliminate the untoward effects. Further, <em>Shodhita </em>(processed) <em>Jayapala </em>seeds have markedly increased the intestinal motility confirms the <em>Virechana </em>(purgation) <em>karma</em> of drug in mice.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2019-03-25 13:30:00
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/19087
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 9, ##issue.no## 4 (2018): December, 2018
 
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