Record Details

Targeted Delivery of siRNA Therapeutics using Ligand Mediated Biodegradable Polymeric Nanocarriers

IR@CSIR-NEERI

View Archive Info
 
 
Field Value
 
Title Targeted Delivery of siRNA Therapeutics using Ligand Mediated Biodegradable
Polymeric Nanocarriers
 
Creator Hong, Seo-Jin
Cho, Kye-Soo
Ahn, Min-Hye
Pal, Sukdeb
Choung, Pill-Hoon
Sangshetti, Jaiprakash
Arote, Rohidas B.
 
Subject Chemistry, Chemical Technology
 
Description Background: Cancer poses a major public health issue, is linked with high mortality rates across the
world, and shows a strong interplay between genetic and environmental factors. To date, common therapeutics,
including chemotherapy, immunotherapy, and radiotherapy, have made significant contributions to cancer treatment,
although diverse obstacles for achieving the permanent “magic bullet” cure have remained. Recently, various
anticancer therapeutic agents designed to overcome the limitations of these conventional cancer treatments
have received considerable attention. One of these promising and novel agents is the siRNA delivery system;
however, poor cellular uptake and altered siRNA stability in physiological environments have limited its use in
clinical trials. Therefore, developing the ideal siRNA delivery system with low cytotoxicity, improved siRNA
stability in the body’s circulation, and prevention of its rapid clearance from bodily fluids, is rapidly emerging as
an innovative therapeutic strategy to combat cancer. Moreover, active targeting using ligand moieties which bind
to over-expressed receptors on the surface of cancer cells would enhance the therapeutic efficiency of siRNA.
Conclusion: In this review, we provide 1) an overview of the non-viral carrier associated with siRNA delivery for
cancer treatment, and 2) a description of the five major cancer-targeting ligands.
 
Publisher Bentham Science Publishers
 
Date 2018
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/1209/1/s6.pdf
Hong, Seo-Jin and Cho, Kye-Soo and Ahn, Min-Hye and Pal, Sukdeb and Choung, Pill-Hoon and Sangshetti, Jaiprakash and Arote, Rohidas B. (2018) Targeted Delivery of siRNA Therapeutics using Ligand Mediated Biodegradable Polymeric Nanocarriers. Current Pharmaceutical Design, 24 (45). pp. 1788-1800. ISSN 1381-6128, ESSN: 1873-4286
 
Relation https://benthamscience.com/journals/current-pharmaceutical-design/
http://neeri.csircentral.net/1209/