Record Details

An Approach to In Silico Dissection of Bacterial Intelligence Through Selective Genomic Tools

IR@CSIR-NEERI

View Archive Info
 
 
Field Value
 
Title An Approach to In Silico Dissection of Bacterial Intelligence
Through Selective Genomic Tools
 
Creator Talkal, Reshma
Tikariha, Hitesh Tikariha
Purohit, H. J.
 
Subject Microbiology
 
Description All the genetic potential and the intelligence a
bacteria can showcase in a given environment are embedded
in its genome. In this study, we have presented systematic
guidelines to understand a bacterial genome with
the relevant set of in silico tools using a novel bacteria as
an example. This study presents a multi-dimensional
approach from genome annotation to tracing genes and
their network of metabolism operating in an organism. It
also shows how the sequence can be used to mine the
enzymes and construction of its 3-dimensional structure so
that its functional behavior can be predicted and compared.
The discriminating algorithm allows analysis of the promoter
region and provides the insight in the regulation of
genes in spite of the similarity in its sequences. The ecological
niche specific bacterial behavior and adapted
altered physiology can be understood through the presence
of secondary metabolite, antibiotic resistance genes, and
viral genes; and it helps in the valorization of genetic
information for developing new biological application/
processes. This study provides an in silico work plan and
necessary steps for genome analysis of novel bacteria
without any rigorous wet lab experiments.
 
Publisher Springer
 
Date 2018
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/1212/1/Talkal2018_Article_AnApproachToInSilicoDissection.pdf
Talkal, Reshma and Tikariha, Hitesh Tikariha and Purohit, H. J. (2018) An Approach to In Silico Dissection of Bacterial Intelligence Through Selective Genomic Tools. Indian Journal of Microbiology, 58 (3). pp. 278-286. ISSN 0046-8991, ESSN: 0973-7715
 
Relation https://link.springer.com/journal/12088
http://neeri.csircentral.net/1212/