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Exploring the rearrangement of sensory intelligence in proteobacteria: insight of Pho regulon

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Title Exploring the rearrangement of sensory intelligence in proteobacteria:
insight of Pho regulon
 
Creator Jha, Varsha
Tikariha, Hitesh
Dafale, N. A.
Purohit, H. J.
 
Subject Microbiology
 
Description Pho regulon is a highly evolved and conserved mechanism across the microbes to fulfil their phosphate need. In this study,
52 proteobacteria genomes were analyzed for the presence of phosphorus acquisition genes, their pattern of arrangement
and copy numbers. The diverse genetic architecture of the Pho regulon genes indicates the evolutionary challenge of nutrient
limitation, particularly phosphorus, faced by bacteria in their environment. The incongruence between the Pho regulon
proteins phylogeny and species phylogeny along with the presence of additional copies of pstS and pstB genes, having cross
similarity with other genera, suggest the possibility of horizontal gene transfer event. The substitution rate analysis and
multiple sequence alignment of the Pho regulon proteins were analyzed to gain additional insight into the evolution of the
Pho regulon system. This comprehensive study confirms that genes perform the regulatory function (phoBR) were vertically
inherited, whereas interestingly, genes whose product involved in direct interaction with the environment (pstS) acquired by
horizontal gene transfer. The substantial amino acid substitutions in PstS most likely contribute to the successful adaptation of
bacteria in different ecological condition dealing with different phosphorus availability. The findings decipher the intelligence
of the bacteria which enable them to carry out the targeted alteration of genes to cope up with the environmental condition.
 
Publisher Springer
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/1226/1/Jha2018_Article_ExploringTheRearrangementOfSen.pdf
Jha, Varsha and Tikariha, Hitesh and Dafale, N. A. and Purohit, H. J. Exploring the rearrangement of sensory intelligence in proteobacteria: insight of Pho regulon. World Journal of Microbiology and Biotechnology, 34 (172). pp. 1-14. ISSN 0959-3993, ESSN: 1573-0972
 
Relation https://link.springer.com/journal/11274
http://neeri.csircentral.net/1226/