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DEVELOPMENT AND EVALUATION OF ACECLOFENAC LOADED MUCOADHESIVE MICROPARTICLES

Shodhganga@INFLIBNET

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Title DEVELOPMENT AND EVALUATION OF ACECLOFENAC LOADED MUCOADHESIVE MICROPARTICLES
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Contributor Dr.N.Narayanan
 
Subject —
 
Description The present study was aimed to develop and evaluate the mucoadhesive
newlinemicrocapsules of Aceclofenac. Aceclofenac is a non-steroidal anti-inflammatory drug
newlineused for relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and
newlineankylosing spondylitis. It has a short biological half life of 3-4 h. The conventional
newlineAceclofenac tablets administered 2 to 3 times a day due to its short biological half life
newlineproduces side effects like gastric ulceration and gastric bleeding. The side effects of
newlineconventional Aceclofenac tablet have been attenuated by designing the drug in the form
newlineof mucoadhesive microcapsules. The mucoadhesive microcapsules of Aceclofenac were
newlineformulated by orifice ionic gelation method and emulsification ionic gelation method
newlineemploying polymers like Hydroxypropyl methyl cellulose, Sodium carboxy methyl
newlinecellulose, Methyl cellulose and Carbopol along with Sodium alginate in the drug polymer
newlineratio 1:1 and 1:2.
newlineFT-IR study was carried out to determine any drug polymer interaction. The study
newlinerevealed that there was no interaction between the polymers and drug. Prepared
newlinemicrocapsules were evaluated for particle size, SEM analysis, percentage yield, flow
newlineproperties, drug content, drug entrapment efficiency, percentage moisture loss, swelling
newlineproperty, in vitro drug release, drug release kinetics and in vitro wash-off test. The
newlinemicrocapsules should exhibit good flow property during filling into the capsules. So the
newlineformulations were evaluated for micromeritic parameters and the values were found to be
newlinewithin the prescribed limits for all formulations.
newlineThe microcapsules were discrete, spherical and free flowing. Average particle size
newlinewas found in the range of 922.3±2.36and#956;m to 977.5±5.21and#956;m in orifice ionic gelation
newlinemethod and 736.4±3.36and#956;m to 862.7±5.71and#956;m in emulsification ionic gelation method.
newlineLow coefficient of variation (lt 2.0%) in percentage drug content of all formulations
newlineindicates uniform distribution of drug throughout the microcapsules.
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Date 2017-06-09T06:06:40Z
2017-06-09T06:06:40Z
9-2-2009
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19-08-2016
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/153327
 
Language English
 
Relation —
 
Rights university
 
Format —
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CD
 
Coverage —
 
Publisher Thanjavur
Periyar Maniammai University
Department of Biotechnology
 
Source University