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DEVELOPMENT OF TIME DELAYED CAPSULE DEVICE FOR CHRONOPHARMACEUTICAL DRUG DELIVERY SYSTEM OF DILTIAZEM HYDROCHLORIDE

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Title DEVELOPMENT OF TIME DELAYED CAPSULE DEVICE FOR CHRONOPHARMACEUTICAL DRUG DELIVERY SYSTEM OF DILTIAZEM HYDROCHLORIDE
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Contributor Dr.K.S.G.Arul kumaran
 
Subject Pulsincap; Colon-specific device; Chronotherapeutics; Eudragit Microspheres.
 
Description Objective: This study has investigated on oral colon specific, pulsincap device to
newlineachieve time and/or site specific release of Diltiazem Hydrochloride based on
newlinechronopharmaceutical consideration. The basic design consists of an insoluble hard
newlinegelatin capsule body filled with Polymethacrylates Polymers containing
newlinemicrospheres of Diltiazem Hydrochloride and sealed with a hydrogel plug. The
newlineentire device was enteric coated, so that the variability in gastric emptying time can
newlinebe overcome and a colon-specific release can be achieved.
newlineMethods: The Diltiazem microspheres were prepared by solvent evaporation method
newlinewith EudragitL-100, S-100, RLPO, RSPO, RL100, RS100, Ethyl cellulose, PVP-K-90
newline(1:1,1:2) by varying drug to polymer ratio and evaluated for the FTIR ,DSC, partic le
newlinesize, percentage yield, drug content, SEM, and in-vitro release study.
newlineResults: The drug content was in the range of 85.21±0.071to 98.935±0.137%. The invitro,
newlinedrug release studies were carried out using pH 6.8 phosphate buffer for 12 hrs.
newlineAt the end of 12th hour the drugs release in the range of 54.29±0.86% to98.96±0.86 %
newlineand from the obtained results; FM13 was selected as an optimized formulation for
newlinedesigning pulsincap device. Different hydrogel polymers (HPMC, Guar gum, Sodium
newlinealginate) were used as plugs in different ratios, to maintain a suitable lag period. The
newlineentire device was coated with 5% CAP. The formulated pulsatile device was
newlineevaluated weight variation, thickness of CAP, FTIR, and in-vitro release study. The
newlinein-vitro release study was carried out using pH 1.2 buffer for a period of 2 hrs then
newlinepH7.4 phosphate buffer for a period of 3hrs then pH6.8 phosphate buffer for a period
newlineof 24 hrs. At the end of 24th hour the drug releases were in the ranges of
newline98.276±0.860%,99.265±0.859%,98.003±0.860%,99.041±0.857%,99.533±0.848%,98.
newline065±0.845%,98.963±0.860%,97.791±0.857%,99.758±0.846%,97.835±0.845%,99.87
newline±0.844% and 99.985±0.845% with HPMC ,Guar gum, and Sodium alginate plugs
newlinerespectively.
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Date 2017-06-13T09:16:53Z
2017-06-13T09:16:53Z
16-11-2009
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22-04-2017
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/154395
 
Language English
 
Relation —
 
Rights university
 
Format —
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CD
 
Coverage —
 
Publisher Thanjavur
Periyar Maniammai University
Department of Biotechnology
 
Source University