Record Details

Polymorphic regions in the interleukin 1 fc gamma receptors tnfa genes and susceptibility to chronic periodontitis a genetic association study

Shodhganga@INFLIBNET

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Title Polymorphic regions in the interleukin 1 fc gamma receptors tnfa genes and susceptibility to chronic periodontitis a genetic association study
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Contributor Suresh rao
 
Subject —
Aassociation study.
Chronic periodontitis
Factor alpha
Fc Gamma receptor
Gene polymorphism
Interleukin
Tumor necrosis
 
Description The present study evaluated the association between the SNP s in IL1 A (-889, +4845), IL1B 511 3954 and FCGR2A H131R FCGR2B Ile 232Thre TNFA 1031 863 and periodontitis susceptibility in a hospital based cohort from South India. In addition a co-relation of the gingival crevicular fluid levels of Interleukin beta and Tumor necrosis factor alpha with the SNP genotype IL1B 511 3954 TNFA 1031 863 was also performed to assess the functionality of the SNP. Linkage disequilibrium analysis and Mult factorial dimensionality reduction analysis was also performed to identify the presence of any interaction between SNP of the genes evaluated A combination of Sanger sequencing and Real time SNP genotyping methods was used to identify the genotypes and cytometric bead array for the protein assessment in gingival crevicular fluid. A significantly higher distribution of the variant alleles in IL1B 3954 IL1RN FCGR2A H131R was observed amongst subjects with chronic periodontitis. An increase in risk ranging from 175 19 was observed when the subjects carried the variant alleles of the IL1B 3954 IL1RN, FCGR2A H131R
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Summary p. 196-197 Reference p.198-238
 
Date 2017-07-24T08:42:41Z
2017-07-24T08:42:41Z
01/10/2007
12/07/2017
12/07/2017
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/160678
 
Language English US
 
Relation —
 
Rights self
 
Format 1-255
30cms
None
 
Coverage PERIODONTOLOGY AND HUMAN GENETICS
 
Publisher Chennai
Sri Ramachandra University
Dental College
 
Source University