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Hybrid functional biopolymers as advanced nanocomposite for catalytic drug delivery and sensing applications

Shodhganga@INFLIBNET

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Title Hybrid functional biopolymers as advanced nanocomposite for catalytic drug delivery and sensing applications
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Contributor Choudhury Devasish
 
Subject Biopolymers
Catalytic drug
Chemistry
Nanocomposite
Sensing application
 
Description Nanocomposites offer unique combinations of property and design, a major limitation
newlinein the conventional microcomposites. In this class, hybrid functional bionanocomposites
newlinehave been introduced as an advanced and versatile generation providing miniaturisation
newlineas well as hybridisation between organic and inorganic functions. Be it applications like
newlinedrug delivery, sensing or catalysis, these hybrid bionanocomposites on par have proved
newlinetheir excellence.
newlineIn the thesis, these studies laid the grounds framing the main objective to investigate
newlinethe feasibility of three different polysaccharides, viz., chitosan, alginate and agarose to
newlineform hybrid bionanocomposites which are variedly functional. The initial work
newlineintroduces chitosan gel and tea as two new precursors for the synthesis of carbon dots
newline(CD) having particle size less than 10 nm. The CDs from both the sources showed
newlinebright blue fluorescence under UV lamp with sharp peaks in their photoluminescence
newline(PL) spectra. The unique property variance between these two carbon dots was observed
newlinein their net surface charge with chitosan gel CDs showing positive value (and#950;= +27.8 mv),
newlineand tea CDs showing negative value (and#950;= 39.2 mV). In addition, the photoluminescent
newlineproperties of chitosan CDs at different pH conditions and on incorporation of silver and
newlinegold nanoparticles were examined. Interestingly, when chitosan carbon dots combined
newlinewith calcium alginate (CA) beads formed a protective coat on the beads. These carbon
newlinedots coated alginate beads (CA-CD) showed exceptional stability at room temperature
newline(even after 60 days) and also at higher temperature. The CA-CD beads showed their
newlineproficiency as a pH dependent drug delivery vehicle taking tetracycline (TC) and
newlinetetracycline:and#946;-cyclodextrin (ß-TC) as model drug systems. The TC loading was 35% for
newlineCA and 77% for CA-CD, and ß-TC loading was 48% for CA and 90% for CA-CD. A
newlinemaximum drug release at pH 1 was obtained with 70% for CA-CD and 37% CA at 96 h.
newlineHowever, in case of ß-TC loading the delivery rates were slower showing 61% relea
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Date 2017-05-29T10:06:27Z
2017-05-29T10:06:27Z
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2016
31/01/2017
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/152176
 
Language English
 
Relation n.d.
 
Rights university
 
Format vi, 187 p.
33 cm
DVD
 
Coverage Chemistry
 
Publisher Guwahati
Gauhati University
Department of Chemistry
 
Source University