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Investigating the Molecular Mechanisms Involved in Neuroprotective Effect of Remote Limb Ischemic Post Conditioning against Cerebral Ischemic Reperfusion Injury and Associated Cognitive Deficits

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Title Investigating the Molecular Mechanisms Involved in Neuroprotective Effect of Remote Limb Ischemic Post Conditioning against Cerebral Ischemic Reperfusion Injury and Associated Cognitive Deficits
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Contributor Rajeev Taliyan
 
Subject —
Molecular Mechanisms Involved in Neuroprotective Effect
Pharmacy,
Remote Limb Ischemic Post Conditioning against Cerebral Ischemic Reperfusion Injury
 
Description According to World Health Organisation (WHO), vascular disorders accounts for the major cause of the death worldwide, where stroke ranks second position in frequency and importance as the leading cause of mortality and associated inabilities like speech, anxiety, depression and
newlinecognition deficits. Following an acute ischemic attack, early and successful cerebral reperfusion with the use of thrombolytics/mechanical endovascular procedures is the available strategy to
newlinereduce the pathological outcomes. However, the process of restoring blood flow to ischemic brain tissue may induce reperfusion injury i.e. cerebral ischemic reperfusion (I/R) injury. Although the molecular mechanisms of cerebral I/R injury are not clear, the depletion of
newlineenergy during ischemia and the induction of oxidative stress during reperfusion have been reported to initiate a cascade of energy failure/deficit, ionic imbalance, calcium overload, excitotoxicity, increased neuroinflammation, mitochondrial dysfunction and apoptosis that lead
newlineto cell death followed by severe organ failure. Moreover, all these processes may concurrently lead to significant changes in gene expression leading to epigenetic modifications. The thrombolytic, tissue Plasminogen Activator (tPA) is the only Food and Drug Administration
newline(FDA) drug with a narrow therapeutic window of 4-6 hrs and may result in serious side effects like intracerebral hemorrhage. In decades of past research on cerebral I/R injury, numerous
newlinepreclinical investigations with promising results, could not provide any effective treatment in clinical trials. Thus, there is a pressing need to develop effective treatment strategy with fruitful
newlineclinical translation. The ongoing research is therefore directed towards retrieving the underlying endogenous
newlinemechanisms to induce ischemic tolerance. Ischemic Preconditioning (IPC) refers to non injurious cycles of ischemia and reperfusion applied to vital arteries to provide protection against prolonged I/R injury. Moreover, ischemic Postcond
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Date 2018-10-16T06:12:06Z
2018-10-16T06:12:06Z
01/08/2013
22/07/2017
22/07/2017
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/218657
 
Language English
 
Relation —
 
Rights university
 
Format —
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DVD
 
Coverage —
 
Publisher Pilani
Birla Institute of Technology and Science
Pharmacy
 
Source University