Record Details

Nanoporous imprinted polymers (nanoMIPs) for controlled release of cancer drug

IR@CSIR-NEERI

View Archive Info
 
 
Field Value
 
Title Nanoporous imprinted polymers (nanoMIPs) for controlled release of cancer
drug
 
Creator Korde, Bhagyashree A.
Mankar, Juili S.
Phule, Sumidha
Krupadam, Reddithota J.
 
Subject Chemistry, Chemical Technology
 
Description In this article, a new approach to directly synthesize drug molecule imbedded in the nanometer sized polymer
particles is reported. Molecular imprinting is used to prepare polymers for drug specific for selectively loading of
a desired drug. Computer simulations were performed to provide mechanistic insights on the binding modalities
of model cancer drug, amygdalin with the polymer precursors. Controlled release of amygdalin from nanoMIPs
was studied in vitro cell test and monitoring the absorbance at λem of 390 nm by fluorescence. The nanoparticles
imprinted with amygdalin (nanoMIPs) showed high drug loading (0.98 mg g−1) and also releases drug in a
controlled way without burst release. The polymer releases amygdalin 0.095 μg (5 min), 0.120 μg (30 min),
0.180 μg (180 min), 0.205 μg in 300 min in de-ionized water and similar pattern of release was observed in buffer
2 and 7. The sustained release of drug from nanoMIPs follows Fickian diffusion; and uniformity in nanoMIPs size
have significant impact on release of drug. Swelling of nanoMIP is one of the dominant factors influencing the
drug release patterns. The imprinting procedure and the studies reported in this study would be highly useful in
future for cancer drug administration.
 
Publisher Elsevier
 
Date 2019
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://neeri.csircentral.net/1243/1/1-s2.0-S0928493118325827-main.pdf
Korde, Bhagyashree A. and Mankar, Juili S. and Phule, Sumidha and Krupadam, Reddithota J. (2019) Nanoporous imprinted polymers (nanoMIPs) for controlled release of cancer drug. Materials Science & Engineering C, 99. pp. 222-230. ISSN 0928-4931
 
Relation http://www.elsevier.com/locate/msec
http://neeri.csircentral.net/1243/