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Recent advances in nanoparticle based aptasensors for food contaminants.

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Relation http://ir.cftri.com/14097/
http://dx.doi.org/10.1016/j.bios.2015.07.017
 
Title Recent advances in nanoparticle based aptasensors for food
contaminants.
 
Creator Richa, Sharma
Ragavan, K. V.
Thakur, M. S.
Raghavarao, K. S. M. S.
 
Subject 01 Biotechnology and Bioengineering
02 Safety
 
Description Food safety and hazard analysis is a prime concern of human life, thus quality assessment of food and
water is the need of the day. Recent advances in nano-biotechnology play a significant role in providing
possible solutions for developing highly sensitive and affordable detection tools for food analysis. Nanomaterials
based aptasensors hold great potential to overcome the drawbacks of conventional analytical
techniques. Aptamers comprise a novel class of highly specific bio-recognition elements which are
produced by SELEX (systematic evolution of ligands by exponential enrichment) process. They bind to
target molecules by folding into 3D structures that can discriminate different chiral compounds. The
flexibility in making modifications in aptamers contribute to the design of biosensors, enabling the
generation of bio-recognition elements for a wide variety of target molecules. Nanomaterials such as
metal nanoparticles, metal nanoclusters, metal oxide nanoparticles, metal and carbon quantum dots,
graphene, carbon nanotubes and nanocomposites enable higher sensitivity by signal amplification and
introduce several novel transduction principles such as enhanced chemiluminescence, fluorescence,
Raman signals, electrochemical signals, enhanced catalytic activity, and super-paramagnetic properties
to the biosensor. Although there are a few reviews published recently which deal with the potential of
aptamers in various fields, none are devoted exclusively to the potential of aptasensors based on nanomaterials
for the analysis of food contaminants. Hence, the current review discusses several transduction
systems and their principles used in aptamer based nanosensors which have been developed in
the past five years, the challenges faced in their designing, along with their strengths and limitations.
 
Date 2015
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14097/1/Biosensors%20and%20Bioelectronics%2074%20%282015%29%20612%E2%80%93627.pdf
Richa, Sharma and Ragavan, K. V. and Thakur, M. S. and Raghavarao, K. S. M. S. (2015) Recent advances in nanoparticle based aptasensors for food contaminants. Biosensors and Bioelectronics, 74. pp. 612-627. ISSN 0956-5663