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Microbial collagenases: challenges and prospects in production and potential applications in food and nutrition.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/14130/
https://doi.org/10.1039/c5ra23316j
 
Title Microbial collagenases: challenges and prospects
in production and potential applications in food
and nutrition.
 
Creator Gaurav Kumar, Pal
Suresh, P. V.
 
Subject 05 Enzymes
Fish
 
Description Microbial collagenases are promising enzymes in view of their extensive industrial and biological
applications. The emerging evidence of potential food applications and health benefits have revealed
that microbial collagenase shows significant promise as a main component for bioactive functional
ingredients and the preparation of peptides. Collagenases are important virulence factors which play
a crucial role in the global degradation of the extracellular matrices of animals, due to their collagen
degradation ability. There is a lack of scientific consensus on a well-defined and proper screening of
collagenase-producing microorganisms. A vast controversy can be found in the literature regarding the
correct identification of microbial collagenase. This review summarizes the current technologies and
strategies used to improve the screening, production, and purification of microbial collagenase with
a comprehensive insight, especially focusing on the classification, structures and collagen-degrading
mechanisms of M9 family representative collagenases. It also highlights the potential of microbial
collagenase in the development of a process for meat tenderization and bioactive “true” collagen
peptides, or the preparation of hydrolysates. In addition, the critical challenges and various strategies for
potential applications of collagenase in food, nutrition, biotechnological and medical sectors are
highlighted.
 
Date 2016
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14130/1/RSC%20Adv.%2C%202016%2C%206%2C%2033763.pdf
Gaurav Kumar, Pal and Suresh, P. V. (2016) Microbial collagenases: challenges and prospects in production and potential applications in food and nutrition. RSC Advances, 6. 33763–-33780.