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Immunomodulatory and anti invasive properties of some naturally occurring terpenoids

Shodhganga@INFLIBNET

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Title Immunomodulatory and anti invasive properties of some naturally occurring terpenoids
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Contributor —
 
Subject Immunology
Vernolide-A
Nomilin and Oleanolic acid
Immunomodulation
Metastasis
Hypoxia
Angiogenesis
Apoptosis
Proinflammatory cytokines
NF-and#954;B
 
Description Cancer, one of the leading causes of death world-wide is a genetic disease that usually arises from the accumulation of several mutations. Cancer cells are characterized by a failure of cell cycle control which results in their over proliferation. It is estimated that about 9 million new cancer cases are diagnosed every year and over 4.5 million people die from cancer each year in the world. Cancer rates in India are considerably lower than those in more developed countries such as the United States. Data from population based cancer registries in India show that the most frequently reported cancer sites in males are lung, oesophagus, stomach, and larynx. In females, cancers of the cervix, breast, ovary, and oesophagus are the most commonly encountered (WHO). The estimated number of new cancers in India per year is about 7 lakhs and over 3.5 lakhs people die of cancer each year. The immune system is known to be involved in the etiology as well as pathophysiolgic mechanism of many diseases. Modulation of immune response is highly relevant in tumour cell destruction. One of the main reasons for the rapid progression of human cancers is the ability of tumour cells to escape from the immune surveillance mechanism of the body. Immunosuppression is one of the major obstacles in the conventional cancer treatment such as chemo and radiotherapy. The effect of Vernonia cinerea L. and Vernolide-A on the immune system were studied using BALB/c mice. Intraperitoneal administration of V.cinerea and Vernolide-A were found to enhance the total WBC count, bone marrow cellularity and number of and#945; - esterase positive cells. Treatment of V.cinerea and Vernolide-A was found to increase the circulating antibody titer and antibody forming cells indicating their stimulatory effect on the humoral arm of immune system. However, increased antibody titre remained several days thereafter indicating that the immunological activity could be sustained for several days. Moreover, V.
Bibliography p.161-188
 
Date 2013-11-22T11:04:00Z
2013-11-22T11:04:00Z
2013-11-22
n.d.
January 2011
n.d.
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/13160
 
Language English
 
Relation -
 
Rights university
 
Format 188p.
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None
 
Coverage Immunology
 
Publisher Kottayam
Mahatma Gandhi University
Amala Cancer Research Centre
 
Source INFLIBNET