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<em>Karonda</em> and <em>Jamun</em> seeds’ <em>in vitro</em> anticancer efficacy

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Title Statement <em>Karonda</em> and <em>Jamun</em> seeds’ <em>in vitro</em> anticancer efficacy
 
Added Entry - Uncontrolled Name Sharma, Vikas
Heer, Arti
Kour, Navneet
Sharma, Akash
Singh, Shashank K
 
Uncontrolled Index Term Karonda; Jamun; Cancer cells; SRB assay; Cytotoxicity
 
Summary, etc. <p class="Abstract">In the search for potential anticancer agents from fruits, the present research work was carried out to examine the <em>in vitro </em>cytotoxic potential of seed part of <em>Carissa carandas </em>(<em>karonda</em>) and <em>Syzygium cumini </em>(<em>jamun</em>) against nine human cancer cell lines from eight different origins namely MCF-7, T-47D (breast), SF-295 (CNS), HCT-116 (colon), A-549 (lung), MDA-MB-435 (melanoma), OVCAR-5 (ovary), PC-3 (prostate) and A-498 (renal). Methanolic extracts were used as test material and anticancer activity was determined <em>via</em> SRB assayat 100 μg/mL. Results revealed that seeds suppressed the proliferation of human cancer cells with growth inhibition range of 78-100% (<em>karonda</em>) and 71-93% (<em>jamun</em>). <em>Karonda</em> seeds exhibited 100% growth inhibition of A-549 and OVCAR-5 cancer cells where as <em>jamun</em> seeds displayed 93% growth inhibition of SF-295 cancer cells. The seeds were then evaluated at lower concentrations of 50, 30, 10 and 1 μg/mL in which seeds exhibit significant <em>in vitro</em> cytotoxic effect against lung cancer cells (A-549). Further, IC<sub>50</sub> values were calculated and it was observed that seed extracts from both the fruits showed IC<sub>50</sub>&lt;10 in case of lung cancer cells whereas <em>karonda</em> seed extract also showed IC<sub>50</sub>&lt;10 in case of colon cancer cells. To conclude, <em>karonda</em> and <em>jamun</em> seeds possess certain constituents with cytotoxic properties that can be used to develop anticancer agents especially for lung cancer therapy and to provide a great service to cancer patients, further studies are required for the isolation of active ingredients from these seeds.</p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2019-07-18 15:58:02
 
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http://op.niscair.res.in/index.php/IJTK/article/view/26747
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 18, ##issue.no## 3 (2019): Indian Journal of Traditional Knowledge
 
Language Note en