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Effect of <em>Radix Platycodonis</em> and <em>Radix Cyathulae</em> in Xuefu Zhuyu Tang on tissue<br />distribution of paeoniflorin in blood-stasis mice by HPLC: Experimental<br />evidence on <em>Shi</em> ingredients in traditional formula compatibility

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Title Statement Effect of <em>Radix Platycodonis</em> and <em>Radix Cyathulae</em> in Xuefu Zhuyu Tang on tissue<br />distribution of paeoniflorin in blood-stasis mice by HPLC: Experimental<br />evidence on <em>Shi</em> ingredients in traditional formula compatibility
 
Added Entry - Uncontrolled Name Verma, Charu ; CSIR-NISCAIR
Huang, Wei
Chen, Yunhui
Tang, Shiyun
Liu, Xinglong
Zhang, Xiaodan
Wan, Peng
Tang, Songqi
 
Uncontrolled Index Term Blood stasis syndrome; Paeoniflorin; Radix cyathulae; Radix platycodonis; Shi ingredient; Tissue distribution; Traditional formula compatibility; Xuefu Zhuyu Tang
 
Summary, etc. Xuefu Zhuyu Tang (XFZY), a famous formula in traditional Chinese medicine, has been demonstrated to show good<br />therapeutic effects on diseases caused by blood stasis syndrome. Two of its eleven herbs, Radix Platycodonis and Radix<br />Cyathulae, have been considered as Shi ingredients in the hierarchy of traditional formula compatibility and proven<br />possessing synergistic properties that strengthen the formula's potency of activating blood circulation and resolving blood<br />stagnation. However, its mechanism is still not clearly elucidated. In our previous study, we observed their effects on<br />paeoniflorin pharmacokinetics of XFZY in rats. In this study, we continued by detecting and comparing their effect on the<br />tissue distribution of paeoniflorin after oral administration of XFZY and its three variants (XFZY without Radix<br />Platycodonis or/and Radix Cyathulae) in blood-stasis mice via HPLC assay. The results indicated that combining usage of<br />Radix Platycodonis and Radix Cyathula increased the distribution of paeoniflorin in the lung and kidney and introduced the<br />paeoniflorin into the liver, spleen and heart. It might explain their synergistic properties that strengthen the formula's effect<br />of invigorating blood and dissolving stasis and provide experimental evidence to understand the pharmacological effects of<br />Shi herbs in the hierarchy of traditional formula compatibility.<br /><br />
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2019-07-18 15:58:02
 
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http://op.niscair.res.in/index.php/IJTK/article/view/26805
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 18, ##issue.no## 3 (2019): Indian Journal of Traditional Knowledge
 
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