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Synthesis and antibacterial activity evaluation of aminoguanidine or dihydrotriazine derivatives

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Title Statement Synthesis and antibacterial activity evaluation of aminoguanidine or dihydrotriazine derivatives
 
Added Entry - Uncontrolled Name Bai, Xueqian
Zhao, Limin
Liu, Zhe
Li, Yan
Zhang, Tianyi
Liu, Xuekun
 
Uncontrolled Index Term Aminoguanidine; Antibacterial activities; Antifungal activities; Cytotoxicity; Dihydrotriazine
 
Summary, etc. <p class="Abstract"><span lang="EN-GB">In the alarming context of rising bacterial antibiotic resistance, there is an urgent need to discover new antibiotics or increase and/or enlarge the activity of those currently in use. In this article, aminoguanidine and dihydrotriazine derivatives were designed, synthesized and evaluated in terms of their antibacterial and antifungal activities. Most of the synthesized compounds showed potent inhibitory activities against different bacteria and one fungus with minimum inhibitory concentrations (MICs) ranging from 1 to 64 <a name="OLE_LINK1">μg/mL</a>, which obviously better than the positives control drug. The compound 23a showed the best antibacterial activities, whose MIC value was 1 μg/mL against eight strains. The cytotoxic activity of the compound 4c, 8a and 23a were assessed in Human liver cancer cells. The preliminary docking results imply that compounds 21b and 23a possibly display their antibacterial activity through the interaction with DHFR protein by targeting residues of the active cavities of DHFR.</span></p><br />
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2019-08-19 11:28:31
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJBB/article/view/27359
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); ##issue.vol## 56, ##issue.no## 4 (2019): IJBB Vol.56(4) [August 2019]
 
Language Note en