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Oxidation products of DNA, lipid and protein among the individuals progressing towards metabolic syndrome

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Title Statement Oxidation products of DNA, lipid and protein among the individuals progressing towards metabolic syndrome
 
Added Entry - Uncontrolled Name Bhutia, Rinchen D
Khandelwal, Bidita
Sherpa, Mingma L
Singh, TA
 
Uncontrolled Index Term DNA damage; Lipid peroxidation; Metabolic syndrome; Oxidative stress; Protein carbonyl
 
Summary, etc. Oxidative stress (OS) is an early event and at the same time also a consequence in the pathology of MetS. We investigated if oxidation markers of DNA, lipid and protein increased with an increase in the risk parameters of MetS. Participants (male:70, female:90 ≥ 20 yrs) were categorized based on the number of risk factors they had as 3 Risk, 2 Risk, 1 Risk and 0 Risk for MetS and were evaluated for various oxidation markers. Protein carbonyl and advanced oxidation protein product (protein oxidation marker) differed significantly between the four study group while malondialdehyde and hydroxynonenal (lipid peroxidation marker) did not. “8-OH dG” (DNA oxidation marker) differed significantly (P< 0.05) while total antioxidant capacity did not demonstrate significant difference in its values across the group (P> 0.05). Pairwise comparison for statistically significant markers(Protein oxidation markers and 8-OH dG), demonstrated that only 8-OH dG differed significantly between 0 Risk- 3 Risk (P< 0.012) but not between 0 Risk -2 Risk and 0 Risk-1 Risk. Oxidative stress markers of DNA, lipid and protein do not increase with an increase in the risk parameters of MetS. However, it is indeed high in MetS with 3 and more risk parameters. Presence of 2 or 1 Risk also increases OS compared to 0 Risk. There is oxidative stress damage in MetS to lipid and protein but DNA damage was of significant consequence.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2019-08-23 17:08:23
 
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http://op.niscair.res.in/index.php/IJBB/article/view/27670
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); ##issue.vol## 56, ##issue.no## 2 (2019): IJBB Vol.56(2) [April 2019]
 
Language Note en