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Evaluation of acetylcholinesterase and butyrylcholinesterase inhibitory activity of Huperzine-A; <em>in silico</em> and <em>in vitro</em> studies

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Title Statement Evaluation of acetylcholinesterase and butyrylcholinesterase inhibitory activity of Huperzine-A; <em>in silico</em> and <em>in vitro</em> studies
 
Added Entry - Uncontrolled Name Upadhyay, Shagun Dubey
Ahmad, Yusra
Kohli, Seema
Sharma, RK
 
Uncontrolled Index Term Acetylcholinesterase; Butyrylcholinesterase; Cognition; Huperzine-A
 
Summary, etc. The present study is focused on exploring the Acetylcholinesterase and Butyrylcholinesterase inhibitory activity of Huperzine-A in silico and in vitro. In this study, Huperzine-A-A was docked with Acetylcholinesterase and Butyrylcholinesterase. Docking studies revealed the excellent interaction of Huperzine-A-A with these targets. The result of present study provides insight for the in vitro studies. The in vitro studies the enzyme kinetics of Huperzine-A-A via Lineweaver brooks plot revealed the kinetics and non-competitive inhibitory nature of the later. Further studies on Huperzine-A-A are necessary to develop and establish its role on brain cholinergic system and cognitive deficits which may serve a stepping stone in CNS medication.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2019-08-23 14:27:09
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJBB/article/view/27646
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); ##issue.vol## 56, ##issue.no## 3 (2019): IJBB Vol.56(3) [June 2019]
 
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