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<em>In silico </em>interaction of hesperidin with some immunomodulatory targets: A docking analysis

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Title Statement <em>In silico </em>interaction of hesperidin with some immunomodulatory targets: A docking analysis
 
Added Entry - Uncontrolled Name Ganeshpurkar, Aditya
Saluja, Ajay
 
Uncontrolled Index Term Cytokines; Hesperidin; Immunomodulatory; Inflammation; Nitric oxide
 
Summary, etc. Forms eternal era, plant, mineral and animal products are used as drugs for the treatment of various diseases. The use of medicinal plants for immunomodulation has a long history. The modern medicinal compounds find their leads in natural products. Immunomodulation amends the immune system of an individual by prying with its usual functions. Discovery of immunomodulators from natural sources has been comprehensively made to modulate the immune system to prevent diseases. Hesperidin has been investigated for its potential anti-inflammatory effects. Hesperidin demonstrated analgesic effects in experimental animals. The present study is focused on exploring the in silico interaction of hesperidin with some chemokines and inflammatory targets. In this study, hesperidin was docked with TNF-α, IL-1β, IL-6, and NOs. Docking studies revealed the excellent interaction of hesperidin with these targets. The result of this work provided an insight into the discovery of novel molecules for immunomodulation and treatment of inflammatory disorders. Additional studies on hesperidin and associated flavonoids are necessary to establish its safety. Hesperidin, can, therefore, can be considered as a candidate for development of an immunomodulatory agent.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2019-08-26 16:17:48
 
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http://op.niscair.res.in/index.php/IJBB/article/view/27731
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); ##issue.vol## 56, ##issue.no## 1 (2019): IJBB Vol.56(1) [February 2019]
 
Language Note en