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Designing of interferon-gamma inducing MHC class-II binders.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Designing of interferon-gamma inducing MHC class-II binders.
 
Creator Dhanda, Sandeep Kumar
Vir, Pooja
Raghava, G.P.S.
 
Subject QR Microbiology
 
Description The generation of interferon-gamma (IFN-γ) by MHC class II activated CD4+ T helper cells play a substantial contribution in the control of infections such as caused by Mycobacterium tuberculosis. In the past, numerous methods have been developed for predicting MHC class II binders that can activate T-helper cells. Best of author's knowledge, no method has been developed so far that can predict the type of cytokine will be secreted by these MHC Class II binders or T-helper epitopes. In this study, an attempt has been made to predict the IFN-γ inducing peptides. The main dataset used in this study contains 3705 IFN-γ inducing and 6728 non-IFN-γ inducing MHC class II binders. Another dataset called IFNgOnly contains 4483 IFN-γ inducing epitopes and 2160 epitopes that induce other cytokine except IFN-γ. In addition we have alternate dataset that contains IFN-γ inducing and equal number of random peptides.
 
Publisher BMC part of Springer Nature
 
Date 2013-12-05
 
Type Article
PeerReviewed
 
Relation https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-8-30
http://crdd.osdd.net/open/2436/
 
Identifier Dhanda, Sandeep Kumar and Vir, Pooja and Raghava, G.P.S. (2013) Designing of interferon-gamma inducing MHC class-II binders. Biology direct, 8. p. 30. ISSN 1745-6150