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In silico models for designing and discovering novel anticancer peptides.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title In silico models for designing and discovering novel anticancer peptides.
 
Creator Tyagi, Atul
Kapoor, Pallavi
Kumar, Rahul
Chaudhary, Kumardeep
Gautam, Ankur
Raghava, G.P.S.
 
Subject QR Microbiology
 
Description Use of therapeutic peptides in cancer therapy has been receiving considerable attention in the recent years. Present study describes the development of computational models for predicting and discovering novel anticancer peptides. Preliminary analysis revealed that Cys, Gly, Ile, Lys, and Trp are dominated at various positions in anticancer peptides. Support vector machine models were developed using amino acid composition and binary profiles as input features on main dataset that contains experimentally validated anticancer peptides and random peptides derived from SwissProt database. In addition, models were developed on alternate dataset that contains antimicrobial peptides instead of random peptides. Binary profiles-based model achieved maximum accuracy 91.44% with MCC 0.83. We have developed a webserver, which would be helpful in: (i) predicting minimum mutations required for improving anticancer potency; (ii) virtual screening of peptides for discovering novel anticancer peptides, and (iii) scanning natural proteins for identification of anticancer peptides (http://crdd.osdd.net/raghava/anticp/).
 
Publisher Nature Publishing Group
 
Date 2013-10-18
 
Type Article
PeerReviewed
 
Relation https://www.nature.com/articles/srep02984
http://crdd.osdd.net/open/2457/
 
Identifier Tyagi, Atul and Kapoor, Pallavi and Kumar, Rahul and Chaudhary, Kumardeep and Gautam, Ankur and Raghava, G.P.S. (2013) In silico models for designing and discovering novel anticancer peptides. Scientific reports, 3. p. 2984. ISSN 2045-2322