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Ethnomedicines’ effects on the process of vascularisation in embryonated chicken eggs

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Title Statement Ethnomedicines’ effects on the process of vascularisation in embryonated chicken eggs
 
Added Entry - Uncontrolled Name Munjal, Ashok
Khandia, Rekha
Singh, Chitra
Mehra, Reena
Dhama, Kuldeep
 
Uncontrolled Index Term Anti-angiogenesis; Chorioallantoic membrane (CAM) assay; Digimizer; Ethnomedicines; Vascularisation
 
Summary, etc. <p class="Abstract">Angiogenesis (vascularisation) is a vivacious progression during embryonic development, which is required for the growth, development, wound healing and maintenance. However, the process may turn into pathological conditions; excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age related macular degeneration, rheumatoid arthritis, etc., whereas insufficient angiogenesis occurs in diseases like coronary artery disease and chronic wounds. Since ancient times, the human population has been dependent on plants for deriving medicines to cure diseases. In the present study, aqueous extract of 04 ethnomedicinal plants parts,<em> Butea monosperma</em> (Kamarkas), <em>Dioscorea hispida</em> (Beychandi), <em>Myristica fragrans</em> (Nutmeg) and <em>Mesua ferrea</em> (Nagkesar), were evaluated for modulation of angiogenesis in chorioallantoic membrane (CAM) of embryonated chicken eggs. Out of these 04, <em>B. monosperma </em>revealed mild inhibitory effects on angiogenesis. <em>M. fragrans</em> and <em>D. hispida</em> inhibited angiogenesis, but also showed detrimental effect on growth of normal CAM with irregular outgrowths in form of projections and uneven thickness. The <em>M. ferrea</em> revealed its potential as antiangiogenic material by inhibiting the vascularisation by reducing the number of blood vessels without effecting normal morphology of CAM tissue. The study paves way to screen ethnomedicinal wealth for screening of plant produce for therapeutic purposes in ameliorating angiogenic disorders.</p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2019-10-18 12:46:46
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/29007
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 18, ##issue.no## 4 (2019): Indian Journal of Traditional Knowledge
 
Language Note en