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Ultraviolet-c haematogenous oxidation therapy of lipopolysaccharide-induced endotoxemia in a rabbit model: A biochemical study

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Title Statement Ultraviolet-c haematogenous oxidation therapy of lipopolysaccharide-induced endotoxemia in a rabbit model: A biochemical study
 
Added Entry - Uncontrolled Name Osman Adam, Gareeballah
Kim, Gi-Beum
Lee, Sei-Jin
Lee, Heeryung
Kim, Shang-Jin
Kim, Jin-Shang
Kang, Hyung-Sub
 
Uncontrolled Index Term Lactate; Lipopolysaccharide (LPS); Magnesium; Metabolic acidosis; Sepsis; Rabbits; Ultraviolet Haematogenous Oxidation Therapy (UV-c HOT)
 
Summary, etc. Systemic inflammatory reaction – due to severe response to toxins of infection associated with immune inhibition – leads to multi-organ dysfunctions and high mortality. Ultraviolet (UV) blood is used for its therapeutic effects when moving across the cells. This study aims to evaluate the impact of UV-c Haematogenous Oxidation Therapy (HOT) in Lipopolysaccharide (LPS)-induced endotoxemia of rabbit model. A total of 40 rabbits randomly divided into four groups, including normal control (NC). LPS and LPS+UV-c HOT groups received 0.1 mg/kg LPS toxin of E. coli, UV-c HOT and LPS+UV-c HOT groups subjected to UV-c HOT treatments once weekly for five times. Blood collected, perfused with oxygen, UV-c directly irradiated into blood, and then auto-transfused. Rabbits were sacrificed after five weeks; blood and serum were collected for analysis. The survival rate, liver, kidney, lipid profile, and blood ions were assessed in treated rabbits. Mortality was 40% in the LPS group, while other groups showed no death. UV-c HOT enhanced critical pH, base deficit, blood gases, hypomagnesemia, hyperlactatemia, and concurrent acidosis. Besides, TNF-α, nitrite, and nitrate were suppressed in response to UV-c HOT. Moreover, UV-c HOT reduced liver and kidney enzymes, improved lipid metabolism, and ameliorated electrolytes homeostasis. Despite that, UV-c HOT performance in ICU for human and animal endotoxemic or septic patients should be evaluated and considered.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2019-12-02 16:28:27
 
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http://op.niscair.res.in/index.php/IJBB/article/view/29224
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); ##issue.vol## 56, ##issue.no## 6 (2019): IJBB Vol.56(6) [December 2019]
 
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