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High expression of nucleophosmin is closely related to the grade and invasion of colorectal cancer

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Title Statement High expression of nucleophosmin is closely related to the grade and invasion of colorectal cancer
 
Added Entry - Uncontrolled Name Yang, Zhaowei
Qiao, Lu
Chao, Yang
Liu, Juan
Di, Yanqing
Sun, Jing
Zhang, Jiebing
Huang, Lihong
Guo, Honghua
He, Chengyan
 
Uncontrolled Index Term Colorectal cancer; NPM1; Two-dimensional LC/MS/MS
 
Summary, etc. To explore the differential protein expression in the colorectal cancer (CRC) patients to validate a new biomarker for tumor progression. CRC tissues and their adjacent non-cancerous tissues were analyzed by two-dimensional LC/MS/MS. Nucleophosmin 1 (NPM1) was selected and confirmed its differential expression by Western blot. Immunohistological staining of NPM1 in tissues was performed to validate its correlation with clinicopathologic parameters of CRC patients. There were 39 candidates with significant difference between cancerous tissues and their adjacent non-cancerous tissues, which included 19 increased proteins and 20 decreased proteins in CRC samples. Especially, NPM1 was correlated with poor differentiation, and lymph node metastasis according to the analysis of patients’ clinicopathologic parameters. Increased expression of NPM1 can be as a critical biomarker for clinical diagnosis of tumor progression of CRC patients.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2019-12-02 16:28:27
 
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http://op.niscair.res.in/index.php/IJBB/article/view/29212
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); ##issue.vol## 56, ##issue.no## 6 (2019): IJBB Vol.56(6) [December 2019]
 
Language Note en