Record Details

Correlation of uric acid levels and purine metabolism enzyme activities in plasma and liver tissues of diabetic rats

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement Correlation of uric acid levels and purine metabolism enzyme activities in plasma and liver tissues of diabetic rats
 
Added Entry - Uncontrolled Name Gowda CV, Yogaraje
S, Senthilkumar
RT, Kashinath
 
Uncontrolled Index Term 5-Nucleotidase; Adenosine deaminase; Alloxan; Diabetes; Xanthine oxidase
 
Summary, etc. The uric acid alteration in human beings causes major health problem due to its pivotal role in the etiology of many systemic diseases. The purine metabolism enzyme activities have a significant role in the process of elevated uric acid in diabetes mellitus. Hence, a study has been undertaken to understand the alteration of these enzyme activities in diabetic condition with an attempt to establish the possible cause for uric acid elevation. Alloxan was administered (150 mg/kg; i.p.) to induce diabetes in rats. Thirty days after alloxan induced diabetes, the enzyme activities were assessed in both plasma and liver tissues. The enzyme activities such as 5<span style="font-family: symbol;"></span>-nucleotidase (5<span style="font-family: symbol;"></span>-NT), adenosine deaminase (ADA), xanthine oxidase (XO) in the plasma and liver tissues were assayed by spectrometric technique and uric acid levels were also measured by Caraway procedure. A significant (P&lt; 0.001) increase in 5<span style="font-family: symbol;"></span>-NT, ADA and XO enzyme activities in plasma and liver tissue with a concomitant increase (P&lt; 0.001) in uric acid levels was observed in diabetic group. The uric acid and the activities of enzymes did not change significantly in control group. From the present study, it can be concluded that an increase in uric acid levels noticed in diabetic condition may be due to increased catabolism of purines as evidenced by increased activities of 5<span style="font-family: symbol;"></span>-NT, ADA and XO enzymes.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2019-12-02 16:28:27
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJBB/article/view/29216
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); ##issue.vol## 56, ##issue.no## 6 (2019): IJBB Vol.56(6) [December 2019]
 
Language Note en