ICAR Research Data Repository for Knowledge Management
Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins: Inducing apoptosis in cancer cells.
DIR@IMTECH: CSIR-Institute of Microbial Technology
View Archive Info| Field | Value | |
| Title |
Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins: Inducing apoptosis in cancer cells.
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| Creator |
Raghav, Pawan Kumar
Kumar, Rajesh Kumar, Vinod Raghava, Gajendra P S |
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| Subject |
QR Microbiology
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| Description |
Inducing apoptosis in cancer cells is an important step for the successful treatment of cancer patients. Bcl-2 is an antiapoptotic protein which determines apoptosis by interacting with proapoptotic members of the Bcl-2 family. Exome sequencing has identified Bcl-2 and Bax missense mutations in more than 40 cancer types. However, a little information is available about the functional impact of each Bcl-2 and Bax mutation on the pathogenesis of cancer.
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| Publisher |
Wiley
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| Date |
2019-11
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| Type |
Article
PeerReviewed |
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| Relation |
https://onlinelibrary.wiley.com/doi/full/10.1002/mgg3.910
http://crdd.osdd.net/open/2488/ |
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| Identifier |
Raghav, Pawan Kumar and Kumar, Rajesh and Kumar, Vinod and Raghava, Gajendra P S (2019) Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins: Inducing apoptosis in cancer cells. Molecular genetics & genomic medicine, 7 (11). e910. ISSN 2324-9269
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