Record Details

Quantitative secretome analysis unravels new secreted proteins in Amphotericin B resistant Leishmania donovani.

DIR@IMTECH: CSIR-Institute of Microbial Technology

View Archive Info
 
 
Field Value
 
Title Quantitative secretome analysis unravels new secreted proteins in Amphotericin B resistant Leishmania donovani.
 
Creator Garg, Gaurav
Ali, Vahab
Singh, Kuljit
Gupta, Parool
Ganguly, Ashish
Sahasrabuddhe, Amogh A
Das, Pradeep
 
Subject QR Microbiology
 
Description Leishmaniasis is second most neglected disease after malaria and seems to be a worldwide concern because of increased drug resistance and non-availability of approved vaccine. The underlying molecular mechanism of drug resistance (Amp B) in Leishmania parasites still remains elusive. Herein, the present study investigated differentially expressed secreted proteins of Amphotericin B sensitive (S) and resistant (R) isolate of Leishmania donovani by using label free quantitative LC-MS/MS approach. A total of 406 differentially expressed secreted proteins were found between sensitive (S) and resistant (R) isolate. Among 406 proteins, 32 were significantly up regulated (>2.0 fold) while 22 were down regulated (
 
Publisher Elsevier Science
 
Date 2019-09-15
 
Type Article
PeerReviewed
 
Relation https://www.sciencedirect.com/science/article/pii/S1874391919302362?via%3Dihub
http://crdd.osdd.net/open/2496/
 
Identifier Garg, Gaurav and Ali, Vahab and Singh, Kuljit and Gupta, Parool and Ganguly, Ashish and Sahasrabuddhe, Amogh A and Das, Pradeep (2019) Quantitative secretome analysis unravels new secreted proteins in Amphotericin B resistant Leishmania donovani. Journal of proteomics, 207. p. 103464. ISSN 1876-7737