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<p><strong><em>In-vitro</em> anti-cancer and <em>in-vivo</em> immunomodulatory activity of two new compounds isolated from wheatgrass (<em>Triticum aestivum</em> L.)<em> </em><em><br /></em></strong><strong></strong></p><p><strong> </strong></p>

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Title Statement <p><strong><em>In-vitro</em> anti-cancer and <em>in-vivo</em> immunomodulatory activity of two new compounds isolated from wheatgrass (<em>Triticum aestivum</em> L.)<em> </em><em><br /></em></strong><strong></strong></p><p><strong> </strong></p>
 
Added Entry - Uncontrolled Name Save, Swati ; Hippocrates Health Institute
Chander, Harish ; Department of Botany, University of Jammu, Jammu, India
Patil, Mahendra ; Center for Excellence in Basic Sciences, University of Mumbai, India
Singh, Surjeet ; Division of Pharmacology, Indian Institute of Integrative Medicine (IIIM) CSIR, Jammu, India
Satti, Naresh Kumar; Division of Natural Plant Chemistry, Indian Institute of Integrative Medicine (IIIM) CSIR, Jammu, India
Chaturbhuj, Ganesh ; Department of Pharmaceutical Sciences and Technology, The Institute of Chemical Technology, Mumbai, India
Clement, Brian ; Comprehensive Cancer Wellness and Life Transformation Program, Hippocrates Health Institute, Florida, USA
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Uncontrolled Index Term natural products chemistry; organic chemistry; cancer prevention; new molecule discovery;
Cytotoxicity assay; Immunomodulator; Lymphocyte proliferation; Structural elucidation; Triticum aestivum; Wheatgrass juice.
 
Summary, etc. <p style="text-align: justify;">Phytotherapeutic agents, or plant-based drugs, are a new class of standardised medicinal agents. In recent years, plant-based therapeutics have been used for the prevention and management of cancer. Practitioners believe that wheatgrass is an effective agent because it contains chlorophyll-like molecules that increase haematopoiesis and strengthen the immune system. This study used wheatgrass juice and powder to substantiate the claim that wheatgrass is an effective anticancer agent. Researchers formulated a new extraction procedure to isolate compounds and subsequently evaluated their bioactivities, particularly their immunomodulatory and anti-cancer activities. This procedure successfully managed to isolate 2 new compounds whose structures were elucidated using Nuclear Magnetic Resonance (NMR), Liquid Chromatography – Mass Spectroscopy (LCMS), and Fourier Transform Infra Red (FTIR) techniques. Both compounds showed unique characteristics with respect to their melting points, colours, odours and solubilities. These 2 novel compounds, a ketone (WG1) and a polyphenol (YWG), exhibited strong <em>in vivo </em>immunomodulatory lymphocyte proliferation and potent <em>in vitro</em> cytotoxic activities against breast, pancreatic, colon, lung, and prostate cancer cell lines. This research concludes that wheatgrass juice and powder includes constituents with medicinal value that can be used for further research as an anti-cancer agent.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2019-12-18 17:17:26
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/17645
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 10, ##issue.no## 1 (2019): March, 2019
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/17645/53002
http://op.niscair.res.in/index.php/IJNPR/article/download/17645/53004
http://op.niscair.res.in/index.php/IJNPR/article/download/17645/465467406
 
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