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<p style="text-align: justify;"><strong>Cell line toxicity study and pharmacological screening of effective nootropic herbal formulation in rat</strong></p>

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Title Statement <p style="text-align: justify;"><strong>Cell line toxicity study and pharmacological screening of effective nootropic herbal formulation in rat</strong></p>
 
Added Entry - Uncontrolled Name Kamila, Shibnath ; Department of Pharmacy Practice, Bharat Institute of Technology, Hyderabad-501510, India
Madhav, N. V. Satheesh ; Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, India
Department of Pharmacy, Manipal University, Karnataka.
 
Uncontrolled Index Term Aloe vera; Cinnamomum zeylanicum; Dementia; Memory; Mentha piperita; Ribes nigrum; Zingiber officinalis.
 
Summary, etc. <p class="Abstract" style="text-align: justify;">The polyphyto drugs FM27; compose of <em>Mentha piperita</em> (10%), <em>Ribes nigrum</em> (20%), <em>Cinnamomum zeylanicum</em> (20%), <em>Aloe vera </em>(10%), <em>Zingiber officinalis </em>(5%), <em>Glycine max </em>(5%) and <em>Avena sativa</em> (30%) on memory acquisition and retention was studied using EPM, MWM and PCA test in rat using two different routes, one is per oral (FM27<sup>O</sup>) and another one is transcranial (FM27<sup>T</sup>). The test drug studied for <em>in vitro</em> safety profile screening by MTT assay in a different cell line. As per the result, cell line toxicity confirmed that formulation FM27 was non toxic in SH-SY-5Y human neuroblastoma cell line, Vero monkey normal kidney epithelial cells, and Chang liver cell line. Test drug FM27<sup>O</sup> studied at a dose of (PO 50 and 100 mg/kg), showed graded dose response and it was observed significantly (p &lt;0.01) effect of memory improvement comparing standard group containing <em>Bacopa monnieri </em>(PO 50 and 100 mg/kg), whereas transcranially applied FM27<sup>T </sup>(10 mg/kg) showed a significant (<em>p</em> &lt;0.001) effect of memory improvement comparing control group and observed similar effect like standard drug. Herbal formulations FM27<sup> </sup>was found to be potent for treating dementia to improve memory. The cell line toxicity study report confirmed it was safe in higher dose also.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2019-12-18 17:17:26
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/20326
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 10, ##issue.no## 1 (2019): March, 2019
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/20326/62404
http://op.niscair.res.in/index.php/IJNPR/article/download/20326/62405
http://op.niscair.res.in/index.php/IJNPR/article/download/20326/62406
http://op.niscair.res.in/index.php/IJNPR/article/download/20326/62407
 
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