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Perspectives of the Artemisia annua dry leaf therapy (ALT) for malaria and of its re-purposement as an affordable cure for artemisinin-treatable illnesses

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Title Perspectives of the Artemisia annua dry leaf therapy (ALT) for malaria and of its re-purposement as an affordable cure for artemisinin-treatable illnesses
 
Creator Goel, Richa
Kumari, Raj
Singh, Vijender
Kumari, Renu
Srivastava, Suchi
Kumar, Sushil
 
Subject Antimalarial Drug-Resistance
Antimalarial Pharmaceuticals
Auto-Immune Diseases
Cancers
Infectious Diseases
Non-Artemisinic Secondary Metabolites
 
Description Accepted date: 6 May 2018
Malarial diseases continue to risk the lives of more than 3 billion people in 97 countries in the world, causing sickness
in several million people and death to half a million patients. The preponderate malaria causing apicomplexan
protozoan parasite species Plasmodium falciparum and Plasmodium vivax have become genetically resistant to
most of the approved antimalarial drugs, including the artemisinin-based combination therapies (ACTs). At this
time, there is a vigorous need to make enough efforts to meet the challenge of combating multi-drug resistant malaria
by (a) speeding up the trials in progress on relatively more effective, new and mechanistically different antimalarial
pharmaceuticals, (b) production of effective vaccines against falciparum and vivax malaria, (c) devising of new ways
to use the presently available anti-malarials such as by using three-drugs ACTs and by using the different two-drug
and three-drug ACTs sequentially, and (d) induction of Artemisia annua dry leaf therapy (ALT) of recent origin, but
of ancient precedent, as an effective treatment for acute and complicated malaria. Here, a perspective type review is
presented of the: pre-ALT antimalarial drugs, methodology of their usage and consequences of resistance development;
safety, efficacy, affordability, quality maintenance and resilience to resistance development aspects of ALT; and
possibilities of ALT re-purposement for treating many infectious-metabolic disorder related- and cancerous-diseases.
In conclusion, an urgent need is emphasized for pilot studies and clinical trials on ALT to attest its deployment as
anti-malarial and cure for diseases beyond malaria.
Authors are grateful to the directors of NIPGR, NBRI
and IICT for the facilities and to Indian National
Science Academy for SK’s association with it as an
honorary emeritus scientist
 
Date 2018-10-05T10:44:16Z
2018-10-05T10:44:16Z
2018
 
Type Article
 
Identifier Proceedings of the Indian National Science Academy 84(3): 731-780
2454-9983
http://223.31.159.10:8080/jspui/handle/123456789/889
http://insajournal.in/insaojs/index.php/proceedings/article/view/458
https://doi.org/10.16943/ptinsa/2018/49411
 
Language en_US
 
Format application/pdf
 
Publisher Indian National Science Academy